Next Article in Journal
A Rare Case of Malonic Aciduria Diagnosed by Newborn Screening in Qatar
Previous Article in Journal
Newborn Screening for Krabbe Disease and Other Lysosomal Storage Disorders: Broad Lessons Learned
Article Menu

Export Article

Open AccessCase Report
Int. J. Neonatal Screen. 2017, 3(1), 4; https://doi.org/10.3390/ijns3010004

The Risk from Anti-Thyroid Hormone Antibody Interference in Neonatal Congenital Hypothyroidism Screening

Clinical Chemistry Laboratory, Department of Pathology, Mater Dei Hospital, Malta
*
Author to whom correspondence should be addressed.
Academic Editor: Peter C.J.I. Schielen
Received: 17 November 2016 / Revised: 20 February 2017 / Accepted: 1 March 2017 / Published: 2 March 2017
View Full-Text   |   Download PDF [180 KB, uploaded 2 March 2017]

Abstract

Neonatal congenital hypothyroidism screening is considered to be one of the most effective newborn screening strategies. Neonatal screening for congenital hypothyroidism involves the analysis of thyroid hormone and thyrotropin levels using an immunoassay based technique. Immunoassays are also prone to analytical problems such as assay interference. Immunoassays used for thyroid hormone measurement are known to be affected from anti-thyroid hormone antibody interference. This is the first reported case of interference presumably caused by anti-thyroid hormone antibodies transferred from mother to child during pregnancy, affecting the measurement of free-thyroxine in a cord-blood sample. We report a case of a full-term newborn with presumed anti-thyroid hormone antibody interference present in both cord blood and subsequent venous blood samples. In the context of a newborn screening programme based solely on thyroxine measurement, this is an important finding, since it has the potential to cause false negative screening results. View Full-Text
Keywords: neonatal hypothyroidism screening; anti-thyroid hormone antibody; interference; cord-blood neonatal hypothyroidism screening; anti-thyroid hormone antibody; interference; cord-blood
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
SciFeed

Share & Cite This Article

MDPI and ACS Style

Brincat, I.; Buhagiar, G. The Risk from Anti-Thyroid Hormone Antibody Interference in Neonatal Congenital Hypothyroidism Screening. Int. J. Neonatal Screen. 2017, 3, 4.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Int. J. Neonatal Screen. EISSN 2409-515X Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top