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Concepts for Developing Physical Gels of Chitosan and of Chitosan Derivatives

1
Department of Life Sciences, University of Trieste, Via Licio Giorgieri 5, I-34127 Trieste, Italy
2
Department of Medicine, Surgery and Health Sciences, University of Trieste, Piazza dell’Ospitale 1, I-34125 Trieste, Italy
*
Authors to whom correspondence should be addressed.
Received: 20 July 2018 / Accepted: 7 August 2018 / Published: 9 August 2018
(This article belongs to the Special Issue Polysaccharide Hydrogels)
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Abstract

Chitosan macro- and micro/nano-gels have gained increasing attention in recent years, especially in the biomedical field, given the well-documented low toxicity, degradability, and non-immunogenicity of this unique biopolymer. In this review we aim at recapitulating the recent gelling concepts for developing chitosan-based physical gels. Specifically, we describe how nowadays it is relatively simple to prepare networks endowed with different sizes and shapes simply by exploiting physical interactions, namely (i) hydrophobic effects and hydrogen bonds—mostly governed by chitosan chemical composition—and (ii) electrostatic interactions, mainly ensured by physical/chemical chitosan features, such as the degree of acetylation and molecular weight, and external parameters, such as pH and ionic strength. Particular emphasis is dedicated to potential applications of this set of materials, especially in tissue engineering and drug delivery sectors. Lastly, we report on chitosan derivatives and their ability to form gels. Additionally, we discuss the recent findings on a lactose-modified chitosan named Chitlac, which has proved to form attractive gels both at the macro- and at the nano-scale. View Full-Text
Keywords: chitosan; gel; physical interactions; gelling mechanisms; tissue engineering; drug delivery; chitosan-derivatives; Chitlac chitosan; gel; physical interactions; gelling mechanisms; tissue engineering; drug delivery; chitosan-derivatives; Chitlac
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
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MDPI and ACS Style

Sacco, P.; Furlani, F.; de Marzo, G.; Marsich, E.; Paoletti, S.; Donati, I. Concepts for Developing Physical Gels of Chitosan and of Chitosan Derivatives. Gels 2018, 4, 67.

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