A Bioactive Hydrogel and 3D Printed Polycaprolactone System for Bone Tissue Engineering
Abstract
:1. Introduction
2. Results
2.1. Hydrogel Preparation
2.2. Rapid Fabrication of the 3D Printed PCL Scaffold
2.3. Hydrogel Retention Capacity of the PCL Scaffolds
2.4. Microstructure Imaging and Characterization of Phases in the PCL Scaffold and Hydrogel System
2.5. Sustained Dissolution of Hydrogel in Simulated Body Fluid (SBF)
2.6. Apatite Formation Ability of the PCL/Gel System
2.7. Cytocompatibility of the PCL/Gel System
3. Discussion
4. Conclusions
5. Materials and Methods
5.1. Materials
5.2. 3D Printing of PCL Scaffold
5.3. Synthesis of Bioactive Hydrogel Infiltrated with hMSC
5.4. Formation of a Hybrid PCL/Hydrogel System
5.5. Cytocompatibility Assessment
5.6. Dissolution Study and Bioactivity Test
5.6.1. Calculation of the Dissolved Amount of Hydrogel
5.6.2. Apatite Formation on the PCL-Gel Samples
5.7. XRD and SEM Analysis
Supplementary Materials
Acknowledgments
Author Contributions
Conflicts of Interest
References
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Hernandez, I.; Kumar, A.; Joddar, B. A Bioactive Hydrogel and 3D Printed Polycaprolactone System for Bone Tissue Engineering. Gels 2017, 3, 26. https://doi.org/10.3390/gels3030026
Hernandez I, Kumar A, Joddar B. A Bioactive Hydrogel and 3D Printed Polycaprolactone System for Bone Tissue Engineering. Gels. 2017; 3(3):26. https://doi.org/10.3390/gels3030026
Chicago/Turabian StyleHernandez, Ivan, Alok Kumar, and Binata Joddar. 2017. "A Bioactive Hydrogel and 3D Printed Polycaprolactone System for Bone Tissue Engineering" Gels 3, no. 3: 26. https://doi.org/10.3390/gels3030026