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Bioresponsive Hydrogels: Chemical Strategies and Perspectives in Tissue Engineering

Department of Biotechnology and Biosciences, University of Milano-Bicocca, 20126 Milano, Italy
Authors to whom correspondence should be addressed.
Academic Editor: Esmaiel Jabbari
Received: 4 August 2016 / Revised: 28 September 2016 / Accepted: 8 October 2016 / Published: 14 October 2016
(This article belongs to the Special Issue Hydrogels in Tissue Engineering)
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Disease, trauma, and aging account for a significant number of clinical disorders. Regenerative medicine is emerging as a very promising therapeutic option. The design and development of new cell-customised biomaterials able to mimic extracellular matrix (ECM) functionalities represents one of the major strategies to control the cell fate and stimulate tissue regeneration. Recently, hydrogels have received a considerable interest for their use in the modulation and control of cell fate during the regeneration processes. Several synthetic bioresponsive hydrogels are being developed in order to facilitate cell-matrix and cell-cell interactions. In this review, new strategies and future perspectives of such synthetic cell microenvironments will be highlighted. View Full-Text
Keywords: hydrogels; tissue engineering; bioconjugation hydrogels; tissue engineering; bioconjugation

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Sgambato, A.; Cipolla, L.; Russo, L. Bioresponsive Hydrogels: Chemical Strategies and Perspectives in Tissue Engineering. Gels 2016, 2, 28.

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