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Gels 2016, 2(1), 6; doi:10.3390/gels2010006

Stimuli Responsive Poly(Vinyl Caprolactam) Gels for Biomedical Applications

1
Department of Polymer Science and Engineering, Pusan National University, Busan 609 735, Korea
2
Department of Chemistry, Yogi Vemana University, Kadapa 516 003, Andhra Pradesh, India
3
Department of Chemical Engineering and Material Science, Wayne State University, Detroit, MI48202, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Dirk Kuckling
Received: 13 November 2015 / Revised: 8 January 2016 / Accepted: 13 January 2016 / Published: 25 January 2016
(This article belongs to the Special Issue Stimuli-Responsive Gels)
View Full-Text   |   Download PDF [1079 KB, uploaded 25 January 2016]   |  

Abstract

Poly(vinyl caprolactam) (PNVCL) is one of the most important thermoresponsive polymers because it is similar to poly(N-isopropyl acrylamide). PNVCL precipitates from aqueous solutions in a physiological temperature range (32–34 °C). The use of PNVCL instead of PNIPAM is considered advantageous because of the assumed lower toxicity of PNVCL. PNVCL copolymer gels are sensitive to external stimuli, such as temperature and pH; which gives them a wide range of biomedical applications and consequently attracts considerable scientific interest. This review focuses on the recent studies on PNVCL-based stimuli responsive three dimensional hydrogels (macro, micro, and nano) for biomedical applications. This review also covers the future outlooks of PNVCL-based gels for biomedical applications, particularly in the drug delivery field. View Full-Text
Keywords: stimuli responsive; gels; poly(vinyl caprolactam); biomedical applications stimuli responsive; gels; poly(vinyl caprolactam); biomedical applications
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Rao, K.M.; Rao, K.S.V.K.; Ha, C.-S. Stimuli Responsive Poly(Vinyl Caprolactam) Gels for Biomedical Applications. Gels 2016, 2, 6.

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