Next Article in Journal
Supramolecular Assembly of pH-Sensitive Triphenylene Derived π-Gelators and Their Application as Molecular Template for the Preparation of Silica Nanotubes
Next Article in Special Issue
Stimuli-Responsive Assemblies for Sensing Applications
Previous Article in Journal
Acknowledgement to Reviewers of Gels in 2015
Previous Article in Special Issue
Synthesis and Characterization of New Functional Photo Cross-Linkable Smart Polymers Containing Vanillin Derivatives
Article Menu

Export Article

Open AccessReview

Stimuli Responsive Poly(Vinyl Caprolactam) Gels for Biomedical Applications

Department of Polymer Science and Engineering, Pusan National University, Busan 609 735, Korea
Department of Chemistry, Yogi Vemana University, Kadapa 516 003, Andhra Pradesh, India
Department of Chemical Engineering and Material Science, Wayne State University, Detroit, MI48202, USA
Author to whom correspondence should be addressed.
Academic Editor: Dirk Kuckling
Received: 13 November 2015 / Revised: 8 January 2016 / Accepted: 13 January 2016 / Published: 25 January 2016
(This article belongs to the Special Issue Stimuli-Responsive Gels)
View Full-Text   |   Download PDF [1079 KB, uploaded 25 January 2016]   |  


Poly(vinyl caprolactam) (PNVCL) is one of the most important thermoresponsive polymers because it is similar to poly(N-isopropyl acrylamide). PNVCL precipitates from aqueous solutions in a physiological temperature range (32–34 °C). The use of PNVCL instead of PNIPAM is considered advantageous because of the assumed lower toxicity of PNVCL. PNVCL copolymer gels are sensitive to external stimuli, such as temperature and pH; which gives them a wide range of biomedical applications and consequently attracts considerable scientific interest. This review focuses on the recent studies on PNVCL-based stimuli responsive three dimensional hydrogels (macro, micro, and nano) for biomedical applications. This review also covers the future outlooks of PNVCL-based gels for biomedical applications, particularly in the drug delivery field. View Full-Text
Keywords: stimuli responsive; gels; poly(vinyl caprolactam); biomedical applications stimuli responsive; gels; poly(vinyl caprolactam); biomedical applications

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Share & Cite This Article

MDPI and ACS Style

Rao, K.M.; Rao, K.S.V.K.; Ha, C.-S. Stimuli Responsive Poly(Vinyl Caprolactam) Gels for Biomedical Applications. Gels 2016, 2, 6.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Metrics

Article Access Statistics



[Return to top]
Gels EISSN 2310-2861 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top