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Gels 2015, 1(1), 3-23; doi:10.3390/gels1010003

New Formulations of Polysaccharide-Based Hydrogels for Drug Release and Tissue Engineering

1
Department of Biotechnology, Chemistry and Pharmacy of University of Siena, Via Aldo Moro 2, 53100 Siena, Italy
2
Interuniversity Research Centre for Advanced Medical Systems (C.R.I.S.M.A.), Viale Giacomo Matteotti 15/16, 53034 Colle di Val d'Elsa, Italy
*
Author to whom correspondence should be addressed.
Academic Editor: David Díaz Díaz
Received: 22 September 2014 / Revised: 10 November 2014 / Accepted: 24 December 2014 / Published: 29 January 2015
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Abstract

Polysaccharide-based hydrogels are very promising materials for a wide range of medical applications, ranging from tissue engineering to controlled drug delivery for local therapy. The most interesting property of this class of materials is the ability to be injected without any alteration of their chemical, mechanical and biological properties, by taking advantage of their thixotropic behavior. It is possible to modulate the rheological and chemical-physical properties of polysaccharide hydrogels by varying the cross-linking agents and exploiting their thixotropic behavior. We present here an overview of our synthetic strategies and applications of innovative polysaccharide-based hydrogels: hyaluronan-based hydrogel and new derivatives of carboxymethylcellulose have been used as matrices in the field of tissue engineering; while guar gum-based hydrogel and hybrid magnetic hydrogels, have been used as promising systems for targeted controlled drug release. Moreover, a new class of materials, interpenetrating hydrogels (IPH), have been obtained by mixing various native thixotropic hydrogels. View Full-Text
Keywords: polysaccharide-based hydrogels; thixotropy; injectable hydrogels; tissue engineering; drug delivery; magnetic nanoparticles polysaccharide-based hydrogels; thixotropy; injectable hydrogels; tissue engineering; drug delivery; magnetic nanoparticles
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Camponeschi, F.; Atrei, A.; Rocchigiani, G.; Mencuccini, L.; Uva, M.; Barbucci, R. New Formulations of Polysaccharide-Based Hydrogels for Drug Release and Tissue Engineering. Gels 2015, 1, 3-23.

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