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J. Fungi 2018, 4(2), 55; https://doi.org/10.3390/jof4020055

Sporotrichin Skin Test for the Diagnosis of Sporotrichosis

1
Dermatology Service & Mycology Department, Hospital General de México, “Dr. Eduardo Liceaga”, Balmis 148, Colonia Doctores, Ciudad de México 06726, Mexico
2
Departamento de Microbiología y Parasitología, Facultad de Medicina, Universidad Nacional Autónoma de México, Ciudad de México 04510, Mexico
3
Medicine School, Universidad Nacional Mayor de San Marcos, Lima 15081, Peru
4
Internal Medicine Department, Hospital General de Zona 29, Instituto Mexicano del Seguro Social, Ciudad de México 07950, Mexico
Current address: Fondo Nacional de Desarrollo Científico y Tecnológico y de Innovación Tecnológica (FONDECYT), CONCYTEC, Lima 51, Peru.
*
Authors to whom correspondence should be addressed.
Received: 1 April 2018 / Revised: 3 May 2018 / Accepted: 5 May 2018 / Published: 9 May 2018
(This article belongs to the Special Issue Sporothrix and Sporotrichosis)
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Abstract

Sporotrichosis is the most common implantation mycosis caused by several species of the Sporothrix schenckii complex. The gold standard for diagnosis is concerned with the isolation of the fungus; although, fresh examinations, staining, and biopsies are also helpful for this purpose. The sporotrichin is an antigenic complex comprised of a peptide-rhamnomannan, which is relevant with respect to pathogenic fungi; it is primarily used for serological and skin testing. We present a study regarding the use of sporotrichin as a diagnostic aid for cutaneous sporotrichosis. Furthermore, 138 cases with suspicion of sporotrichosis were included, 55 of which were proven through cultures. Moreover, out of these 55 cases, 52 (94.5%) tested positive for sporotrichin, while the negative cases corresponded to the disseminated cutaneous forms. We observed a sensitivity of 94.5% and a specificity of 95.2%. We consider that the use of sporotrichin as a skin test helps us as an auxiliary diagnosis before a positive sample culture. View Full-Text
Keywords: sporotrichosis; sporotrichin; skin test; Sporothrix schenckii sporotrichosis; sporotrichin; skin test; Sporothrix schenckii
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Bonifaz, A.; Toriello, C.; Araiza, J.; Ramírez-Soto, M.C.; Tirado-Sánchez, A. Sporotrichin Skin Test for the Diagnosis of Sporotrichosis. J. Fungi 2018, 4, 55.

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