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J. Fungi 2018, 4(1), 36; doi:10.3390/jof4010036

Interactions of Cryptococcus with Dendritic Cells

Department of Microbiology and Molecular Genetics, Oklahoma State University, Stillwater, OK 74078, USA
Received: 22 February 2018 / Revised: 12 March 2018 / Accepted: 14 March 2018 / Published: 15 March 2018
(This article belongs to the Special Issue Cryptococcus and Cryptococcosis)
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Abstract

The fungal pathogens Cryptococcus neoformans and Cryptococcus gattii can cause life-threatening infections in immune compromised and immune competent hosts. These pathogens enter the host via inhalation, and respiratory tract innate immune cells such as dendritic cells (DCs) are one of the first host cells they encounter. The interactions between Cryptococcus and innate immune cells play a critical role in the progression of disease in the host. This review will focus specifically on the interactions between Cryptococcus and dendritic cells (DCs), including recognition/processing by DCs, effects of immune mediators on DC recruitment and activity, and the potential for DC vaccination against cryptococcosis. View Full-Text
Keywords: dendritic cell; Cryptococcus neoformans; Cryptococcus gattii; innate immunity; fungal immunity dendritic cell; Cryptococcus neoformans; Cryptococcus gattii; innate immunity; fungal immunity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Wozniak, K.L. Interactions of Cryptococcus with Dendritic Cells. J. Fungi 2018, 4, 36.

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