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J. Fungi 2018, 4(1), 12; doi:10.3390/jof4010012

Gaining Insights from Candida Biofilm Heterogeneity: One Size Does Not Fit All

1
School of Medicine, Dentistry and Nursing, College of Medical, Veterinary and Life Sciences, Glasgow G2 3JZ, UK
2
Institute of Healthcare Policy and Practice, School of Health, Nursing, and Midwifery, University of the West of Scotland, Paisley PA1 2BE, UK
3
Sandyford Sexual Health Service, NHS Greater Glasgow and Clyde, Glasgow G3 7NB, UK
*
Author to whom correspondence should be addressed.
Received: 1 December 2017 / Revised: 3 January 2018 / Accepted: 9 January 2018 / Published: 15 January 2018
(This article belongs to the Special Issue Candida and Candidiasis)
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Abstract

Despite their clinical significance and substantial human health burden, fungal infections remain relatively under-appreciated. The widespread overuse of antibiotics and the increasing requirement for indwelling medical devices provides an opportunistic potential for the overgrowth and colonization of pathogenic Candida species on both biological and inert substrates. Indeed, it is now widely recognized that biofilms are a highly important part of their virulence repertoire. Candida albicans is regarded as the primary fungal biofilm forming species, yet there is also increasing interest and growing body of evidence for non-Candida albicans species (NCAS) biofilms, and interkingdom biofilm interactions. C. albicans biofilms are heterogeneous structures by definition, existing as three-dimensional populations of yeast, pseudo-hyphae, and hyphae, embedded within a self-produced extracellular matrix. Classical molecular approaches, driven by extensive studies of laboratory strains and mutants, have enhanced our knowledge and understanding of how these complex communities develop, thrive, and cause host-mediated damage. Yet our clinical observations tell a different story, with differential patient responses potentially due to inherent biological heterogeneity from specific clinical isolates associated with their infections. This review explores some of the recent advances made in an attempt to explore the importance of working with clinical isolates, and what this has taught us. View Full-Text
Keywords: Candida; biofilm; antifungal Candida; biofilm; antifungal
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Kean, R.; Delaney, C.; Rajendran, R.; Sherry, L.; Metcalfe, R.; Thomas, R.; McLean, W.; Williams, C.; Ramage, G. Gaining Insights from Candida Biofilm Heterogeneity: One Size Does Not Fit All. J. Fungi 2018, 4, 12.

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