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J. Fungi 2017, 3(1), 6; doi:10.3390/jof3010006

Cutaneous Disseminated and Extracutaneous Sporotrichosis: Current Status of a Complex Disease

Dermatology Service, Mycology Department, Hospital General de México “Eduardo Liceaga”, Balmis 148, Colonia Doctores, CP: 03020. Cd. de México, México
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Author to whom correspondence should be addressed.
Academic Editors: Arnaldo Lopes Colombo and Flavio Queiroz-Telles
Received: 1 December 2016 / Revised: 31 January 2017 / Accepted: 7 February 2017 / Published: 10 February 2017
(This article belongs to the Special Issue Fungal Infections in the Developing World)
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Abstract

Sporotrichosis is an implantation or inoculation mycosis caused by species of Sporothrix schenckii complex; its main manifestations are limited to skin; however, cutaneous-disseminated, disseminated (visceral) and extracutaneous variants of sporotrichosis can be associated with immunosuppression, including HIV-AIDS, chronic alcoholism or more virulent strains. The most common extracutaneous form of sporotrichosis includes pulmonary, osteoarticular and meningeal. The laboratory diagnosis requires observing yeast forms and isolating the fungus; the two main causative agents are Sporothrix schenckii (ss) and Sporothrix brasiliensis. Antibody levels and species recognition by Polimerase Chain Reaction using biological samples or cultures are also useful. The treatment of choice for most cases is amphotericin B and subsequent itraconazole for maintenance therapy. View Full-Text
Keywords: Sporotrichosis; disseminated cutaneous sporotrichosis; AIDS; Sporothrix schenckii; Sporothrix brasiliensis; amphotericin B; itraconazole Sporotrichosis; disseminated cutaneous sporotrichosis; AIDS; Sporothrix schenckii; Sporothrix brasiliensis; amphotericin B; itraconazole
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Bonifaz, A.; Tirado-Sánchez, A. Cutaneous Disseminated and Extracutaneous Sporotrichosis: Current Status of a Complex Disease. J. Fungi 2017, 3, 6.

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