Next Article in Journal
New Trends in Paracoccidioidomycosis Epidemiology
Previous Article in Journal
Special Issue: Novel Antifungal Drug Discovery
Article Menu

Export Article

Open AccessReview
J. Fungi 2016, 2(4), 34; doi:10.3390/jof2040034

The Quest for a Vaccine Against Coccidioidomycosis: A Neglected Disease of the Americas

Departments of Pathology and Medicine, University of California, San Diego, School of Medicine, San Diego, CA 92161, USA
Academic Editor: David S. Perlin
Received: 24 October 2016 / Revised: 2 December 2016 / Accepted: 14 December 2016 / Published: 16 December 2016
View Full-Text   |   Download PDF [937 KB, uploaded 16 December 2016]   |  

Abstract

Coccidioidomycosis (Valley Fever) is a disease caused by inhalation of Coccidioides spp. This neglected disease has substantial public health impact despite its geographic restriction to desert areas of the southwestern U.S., Mexico, Central and South America. The incidence of this infection in California and Arizona has been increasing over the past fifteen years. Several large cities are within the endemic region in the U.S. Coccidioidomycosis accounts for 25,000 hospital admissions per year in California. While most cases of coccidioidomycosis resolve spontaneously, up to 40% are severe enough to require anti-fungal treatment, and a significant number disseminate beyond the lungs. Disseminated infection involving the meninges is fatal without appropriate treatment. Infection with Coccidioides spp. is protective against a second infection, so vaccination seems biologically plausible. This review of efforts to develop a vaccine against coccidioidomycosis focuses on vaccine approaches and the difficulties in identifying protein antigen/adjuvant combinations that protect in experimental mouse models. Although the quest for a vaccine is still in the early stage, scientific efforts for vaccine development may pave the way for future success. View Full-Text
Keywords: Coccidioides immitis; Coccidioides posadasii; coccidioidomycosis; vaccine; immunology; fungi; T-cell mediated immunity Coccidioides immitis; Coccidioides posadasii; coccidioidomycosis; vaccine; immunology; fungi; T-cell mediated immunity
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Kirkland, T.N. The Quest for a Vaccine Against Coccidioidomycosis: A Neglected Disease of the Americas. J. Fungi 2016, 2, 34.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
J. Fungi EISSN 2309-608X Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top