Next Article in Journal
Colliding Epidemics and the Rise of Cryptococcosis
Previous Article in Journal
Masking the Pathogen: Evolutionary Strategies of Fungi and Their Bacterial Counterparts
Previous Article in Special Issue
Role of New Antifungal Agents in the Treatment of Invasive Fungal Infections in Transplant Recipients: Isavuconazole and New Posaconazole Formulations
Article Menu

Export Article

Open AccessReview
J. Fungi 2016, 2(1), 2; doi:10.3390/jof2010002

Phaeohyphomycosis in Transplant Patients

1
Division of Infectious Diseases, Department of Medicine, Wayne State University, 3990 John R. Street, 5 Hudson, Detroit, MI 48201, USA
2
Harper University Hospital, 3990 John R., 5 Hudson, Detroit, MI 48201, USA
Academic Editor: Shmuel Shoham
Received: 13 November 2015 / Revised: 15 December 2015 / Accepted: 17 December 2015 / Published: 22 December 2015
(This article belongs to the Special Issue Fungal Infections in Transplant Recipients)
View Full-Text   |   Download PDF [190 KB, uploaded 19 January 2016]

Abstract

Phaeohyphomycosis is caused by a large, heterogenous group of darkly pigmented fungi. The presence of melanin in their cell walls is characteristic, and is likely an important virulence factor. These infections are being increasingly seen in a variety of clinical syndromes in both immunocompromised and normal individuals. Transplant patients are especially at risk due their prolonged immunosuppression. There are no specific diagnostic tests for these fungi, though the Fontana-Masson stain is relatively specific in tissue. They are generally seen in a worldwide distribution, though a few species are only found in specific geographic regions. Management of these infections is not standardized due to lack of clinical trials, though recommendations are available based on clinical experience from case reports and series and animal models. Superficial infections may be treated without systemic therapy. Central nervous system infections are unique in that they often affect otherwise normal individuals, and are difficult to treat. Disseminated infections carry a high mortality despite aggressive therapy, usually with multiple antifungal drugs. Considerable work is needed to determine optimal diagnostic and treatment strategies for these infections. View Full-Text
Keywords: phaeohyphomycosis; voriconazole; itraconazole; posaconazole; transplantation phaeohyphomycosis; voriconazole; itraconazole; posaconazole; transplantation
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Revankar, S.G. Phaeohyphomycosis in Transplant Patients. J. Fungi 2016, 2, 2.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
J. Fungi EISSN 2309-608X Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top