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Vet. Sci. 2015, 2(3), 111-126; doi:10.3390/vetsci2030111

Cats, Cancer and Comparative Oncology

University of Tennessee College of Veterinary Medicine, 2407 River Drive, Knoxville, TN 37996, USA
Current Address: University of Minnesota Veterinary Clinical Sciences Department, 1352 Boyd Ave, St Paul, MN 55108, USA.
Academic Editor: Jaime F. Modiano
Received: 25 May 2015 / Revised: 17 June 2015 / Accepted: 24 June 2015 / Published: 30 June 2015
(This article belongs to the Special Issue Comparative Pathogenesis of Cancers in Animals and Humans)
View Full-Text   |   Download PDF [99 KB, uploaded 30 June 2015]

Abstract

Naturally occurring tumors in dogs are well-established models for several human cancers. Domestic cats share many of the benefits of dogs as a model (spontaneous cancers developing in an immunocompetent animal sharing the same environment as humans, shorter lifespan allowing more rapid trial completion and data collection, lack of standard of care for many cancers allowing evaluation of therapies in treatment-naïve populations), but have not been utilized to the same degree in the One Medicine approach to cancer. There are both challenges and opportunities in feline compared to canine models. This review will discuss three specific tumor types where cats may offer insights into human cancers. Feline oral squamous cell carcinoma is common, shares both clinical and molecular features with human head and neck cancer and is an attractive model for evaluating new therapies. Feline mammary tumors are usually malignant and aggressive, with the ‘triple-negative’ phenotype being more common than in humans, offering an enriched population in which to examine potential targets and treatments. Finally, although there is not an exact corollary in humans, feline injection site sarcoma may be a model for inflammation-driven tumorigenesis, offering opportunities for studying variations in individual susceptibility as well as preventative and therapeutic strategies. View Full-Text
Keywords: comparative oncology; feline cancer; animal models comparative oncology; feline cancer; animal models
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Cannon, C.M. Cats, Cancer and Comparative Oncology. Vet. Sci. 2015, 2, 111-126.

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