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Bioengineering 2017, 4(3), 77; doi:10.3390/bioengineering4030077

Microdevice Platform for In Vitro Nervous System and Its Disease Model

1,†
,
1,2,†
and
1,*
1
Department of Chemical & Biomolecular Engineering, Sogang University, 35 Baekbeom-ro, Mapo-Gu, Seoul 04107, Korea
2
Department of Chemistry and Chemical Biology, Rutgers, The State University of New Jersey, 610 Taylor Road, Piscataway, NJ 08854, USA
The authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Academic Editor: Hyun Jung Kim
Received: 7 June 2017 / Revised: 7 September 2017 / Accepted: 7 September 2017 / Published: 13 September 2017
(This article belongs to the Special Issue Human Organs-on-Chips for In Vitro Disease Models)
View Full-Text   |   Download PDF [3374 KB, uploaded 13 September 2017]   |  

Abstract

The development of precise microdevices can be applied to the reconstruction of in vitro human microenvironmental systems with biomimetic physiological conditions that have highly tunable spatial and temporal features. Organ-on-a-chip can emulate human physiological functions, particularly at the organ level, as well as its specific roles in the body. Due to the complexity of the structure of the central nervous system and its intercellular interaction, there remains an urgent need for the development of human brain or nervous system models. Thus, various microdevice models have been proposed to mimic actual human brain physiology, which can be categorized as nervous system-on-a-chip. Nervous system-on-a-chip platforms can prove to be promising technologies, through the application of their biomimetic features to the etiology of neurodegenerative diseases. This article reviews the microdevices for nervous system-on-a-chip platform incorporated with neurobiology and microtechnology, including microfluidic designs that are biomimetic to the entire nervous system. The emulation of both neurodegenerative disorders and neural stem cell behavior patterns in micro-platforms is also provided, which can be used as a basis to construct nervous system-on-a-chip. View Full-Text
Keywords: organ-on-a-chip; nervous system-on-a-chip; neuronal interaction; neurodegenerative disease; stem cell organ-on-a-chip; nervous system-on-a-chip; neuronal interaction; neurodegenerative disease; stem cell
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Choi, J.-H.; Cho, H.-Y.; Choi, J.-W. Microdevice Platform for In Vitro Nervous System and Its Disease Model. Bioengineering 2017, 4, 77.

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