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Bioengineering 2017, 4(2), 37; doi:10.3390/bioengineering4020037

Bio-Inspired Multi-Functional Drug Transport Design Concept and Simulations

1
College of Engineering, University of Georgia, Athens, GA 30602, USA
2
Department of Mechanical and Nuclear Engineering, Virginia Commonwealth University, Richmond, VA 23284, USA
3
Previously at Department of Mechanical and Nuclear Engineering, Virginia Commonwealth University, Richmond, VA 23284, USA
This paper is an extended version of our paper published in ASME 2013 Conference on Frontiers in Medical Devices: Applications of Computer Modeling and Simulation, Washington, DC, USA, 11–13 September 2013.
*
Author to whom correspondence should be addressed.
Academic Editor: Hu Yang
Received: 17 February 2017 / Revised: 18 April 2017 / Accepted: 20 April 2017 / Published: 25 April 2017
(This article belongs to the Special Issue Advanced Drug Delivery Systems and Devices)
View Full-Text   |   Download PDF [2459 KB, uploaded 25 April 2017]   |  

Abstract

In this study, we developed a microdevice concept for drug/fluidic transport taking an inspiration from supramolecular motor found in biological cells. Specifically, idealized multi-functional design geometry (nozzle/diffuser/nozzle) was developed for (i) fluidic/particle transport; (ii) particle separation; and (iii) droplet generation. Several design simulations were conducted to demonstrate the working principles of the multi-functional device. The design simulations illustrate that the proposed design concept is feasible for multi-functionality. However, further experimentation and optimization studies are needed to fully evaluate the multifunctional device concept for multiple applications. View Full-Text
Keywords: molecular motors; drug delivery; computer-aided-design; analysis; simulation molecular motors; drug delivery; computer-aided-design; analysis; simulation
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Pidaparti, R.M.; Cartin, C.; Su, G. Bio-Inspired Multi-Functional Drug Transport Design Concept and Simulations. Bioengineering 2017, 4, 37.

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