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Medicines 2018, 5(3), 90; https://doi.org/10.3390/medicines5030090

The Expanding Role of Radiosurgery for Brain Metastases

1
Hall-Edwards Radiotherapy Research Group, Queen Elizabeth Hospital Birmingham, Edgbaston, Birmingham B15 2TH, UK
2
Neuroradiology, Queen Elizabeth Hospital Birmingham, Edgbaston, Birmingham B15 2TH, UK
*
Author to whom correspondence should be addressed.
Received: 23 July 2018 / Revised: 3 August 2018 / Accepted: 7 August 2018 / Published: 14 August 2018
(This article belongs to the Special Issue Advances and Perspectives in Radiotherapy Treatments)
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Abstract

Stereotactic radiosurgery (SRS) has become increasingly important in the management of brain metastases due to improving systemic disease control and rising incidence. Initial trials demonstrated SRS with whole-brain radiotherapy (WBRT) improved local control rates compared with WBRT alone. Concerns with WBRT associated neurocognitive toxicity have contributed to a greater use of SRS alone, including for patients with multiple metastases and following surgical resection. Molecular information, targeted agents, and immunotherapy have also altered the landscape for the management of brain metastases. This review summarises current and emerging data on the role of SRS in the management of brain metastases. View Full-Text
Keywords: stereotactic radiosurgery (SRS); stereotactic radiotherapy (SRT); brain metastasis; immunotherapy; whole brain radiotherapy (WBRT) stereotactic radiosurgery (SRS); stereotactic radiotherapy (SRT); brain metastasis; immunotherapy; whole brain radiotherapy (WBRT)
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
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O’Beirn, M.; Benghiat, H.; Meade, S.; Heyes, G.; Sawlani, V.; Kong, A.; Hartley, A.; Sanghera, P. The Expanding Role of Radiosurgery for Brain Metastases. Medicines 2018, 5, 90.

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