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Medicines 2017, 4(4), 73; https://doi.org/10.3390/medicines4040073

Anti-Diabetic Potential of Ocimum gratissimum Leaf Fractions in Fortified Diet-Fed Streptozotocin Treated Rat Model of Type-2 Diabetes

1
Department of Biochemistry, Ahmadu Bello University, Zaria 811104, Nigeria
2
Directorate of Research and Development, Nigerian Institute of Leather and science Technology, Zaria 810221, Nigeria
*
Author to whom correspondence should be addressed.
Academic Editor: Basil Roufogalis
Received: 16 August 2017 / Revised: 27 September 2017 / Accepted: 5 October 2017 / Published: 11 October 2017
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Abstract

Background: Ocimum gratissimum (OG) is used in the traditional management of diabetes in Nigeria. This study investigated the anti-diabetic potential of OG leaf fractions (OGLF) in a rat model of Type-2 diabetes (T2D). Method: Methanol crude extract of OG leaf was fractionated with solvents of increasing order of polarity (n-hexane, chloroform, ethyl-acetate, n-butanol and water). The anti-diabetic potential of the fractions was evaluated in vivo. T2D was induced in Albino Wistar rats and treated with OGLF. Result: The T2D rats showed significant elevation in serum levels of fasting blood glucose (FBG), liver and kidney function biomarkers. At 4-weeks of intervention with OGLF, the untreated diabetic control group maintained severe hyperglycaemia in the presence of 61.7% serum insulin, 17.3% pancreatic β-cell function (HOMA-β) and 51.5% Insulin sensitivity. The glucose tolerance ability was enhanced in the n-butanol-fraction (OGb) treated group. With 74.8% available serum insulin and 38.6% improvement in insulin sensitivity, the OGb treated group had a 63.5% reduction in FBG and it was found to be most effective as it ameliorates a majority of the changes caused in the studied parameters in diabetic rats. Conclusions: The data from this study suggest that OGb fraction is a potential candidate for the development of an effective drug for the management of T2D. View Full-Text
Keywords: Type-2 diabetes; Ocimum gratissimum; hyperglycaemia; hyperlipidaemia; rats Type-2 diabetes; Ocimum gratissimum; hyperglycaemia; hyperlipidaemia; rats
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
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Okoduwa, S.I.R.; Umar, I.A.; James, D.B.; Inuwa, H.M. Anti-Diabetic Potential of Ocimum gratissimum Leaf Fractions in Fortified Diet-Fed Streptozotocin Treated Rat Model of Type-2 Diabetes. Medicines 2017, 4, 73.

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