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An Aloe Vera-Based Cosmeceutical Cream Delays and Mitigates Ionizing Radiation-Induced Dermatitis in Head and Neck Cancer Patients Undergoing Curative Radiotherapy: A Clinical Study
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Medicines 2017, 4(3), 43; doi:10.3390/medicines4030043

Sandalwood Oil and Turmeric-Based Cream Prevents Ionizing Radiation-Induced Dermatitis in Breast Cancer Patients: Clinical Study

1
Department of Radiation Oncology, Mangalore Institute of Oncology, Mangalore 575002, India
2
Pharmacy Division, Mangalore Institute of Oncology, Mangalore 575002, India
3
Nursing Division, Mangalore Institute of Oncology, Mangalore 575002, India
4
Department of Pharmacology, Father Muller Medical College, Kankanady, Mangalore 575002, India
*
Author to whom correspondence should be addressed.
Academic Editors: Sivarama Vinjamury and Elizabeth Sommers
Received: 9 May 2017 / Revised: 17 June 2017 / Accepted: 22 June 2017 / Published: 24 June 2017
(This article belongs to the Special Issue Complementary and Alternative Medicine for Cancer Patients)
View Full-Text   |   Download PDF [465 KB, uploaded 24 June 2017]   |  

Abstract

Background: The primary objective of this study was to ascertain the benefit of Vicco turmeric Ayurvedic cream (VTC; Vicco Laboratories, Mumbai, India) sandalwood oil and turmeric-based cream in preventing radiodermatitis in women undergoing curative radiotherapy for their breast cancer. Methods and Materials: The study was an investigator-blinded randomized study with Johnsons Baby Oil (JBO; Johnson & Johnson Ltd., Baddi, India) as a comparator, administered daily from the start of radiation therapy for 5 weeks in women receiving breast radiation therapy, 50 Gy in 2 Gy fractions daily for 5 weeks. The endpoints were to ascertain the delay in the appearance and the degree of severity of dermatitis throughout the study period in accordance to the Therapy Oncology Group (RTOG) score. Results: The results indicated that the topical application of VTC delayed and mitigated the radiodermatitis. When compared to the Johnson’s Baby Oil, a significant decrease (p = 0.025) in the incidence of grade 1 was seen at week two, and also in grade 2 and 3 at week 3 (p = 0.003) and week 4 (p = 0.02), respectively, in the VTC cohort. A concomitant decrease in the average severity was also observed at week 2 (p = 0.02), week 3 (p = 0.05) and week 4 (p = 0.03). Conclusions: The results indicate that VTC cream significantly reduces radiation dermatitis when applied to the breast during and after radiation therapy. The result of this study indicates the beneficial effects. Double blind randomized control studies are required to further confirm the beneficial effects of VTC in mitigating radiodermatitis is people undergoing radiation treatment for their cancer. View Full-Text
Keywords: Vicco turmeric; breast cancer; radiation; radiodermatitis Vicco turmeric; breast cancer; radiation; radiodermatitis
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MDPI and ACS Style

Rao, S.; Hegde, S.K.; Baliga-Rao, M.P.; Lobo, J.; Palatty, P.L.; George, T.; Baliga, M.S. Sandalwood Oil and Turmeric-Based Cream Prevents Ionizing Radiation-Induced Dermatitis in Breast Cancer Patients: Clinical Study. Medicines 2017, 4, 43.

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