Next Article in Journal
A Population-Based Cohort Study on the Ability of Acupuncture to Reduce Post-Stroke Depression
Next Article in Special Issue
Physicochemical Properties, Antioxidant and Cytotoxic Activities of Crude Extracts and Fractions from Phyllanthus amarus
Previous Article in Journal
Sino-Austrian High-Tech Acupuncture Network—Annual Report 2015
Previous Article in Special Issue
Interaction of Plant Extracts with Central Nervous System Receptors
Article Menu

Export Article

Open AccessArticle
Medicines 2017, 4(1), 14; doi:10.3390/medicines4010014

Angelica sinensis (Oliv.) Diels: Influence of Value Chain on Quality Criteria and Marker Compounds Ferulic Acid and Z-Ligustilide

1
Institute of Systematic and Evolutionary Botany, University of Zurich, Zollikerstrasse 107, 8008 Zurich, Switzerland
2
Kunming Institute of Botany, Chinese Academy of Sciences, No. 132, Lanhei Road, Kunming 650201, Yunnan, China
3
CAMAG Laboratory, Sonnenmattstrasse 11, 4132 Muttenz, Switzerland
*
Author to whom correspondence should be addressed.
Academic Editor: João Rocha
Received: 23 December 2016 / Revised: 21 February 2017 / Accepted: 24 February 2017 / Published: 14 March 2017
(This article belongs to the Special Issue Herbal Medicines and Functional Foods)
View Full-Text   |   Download PDF [2760 KB, uploaded 14 March 2017]   |  

Abstract

Background: Dang gui (Apiaceae; Angelica sinensis radix) is among the most often used Chinese medicinal plants. However, hardly anything is known about its value chain and its influence on the main marker compounds of the drug. The aim of this study is to investigate the value chain of dang gui in Gansu and Yunnan, and the analysis of the marker compounds ferulic acid and Z-ligustilide concentration in relation to quality criteria such as the production area and size of the roots. Methods: During six months of field research in China, semi-structured interviews with various stakeholders of the value chain were undertaken and plant material was collected. High-performance thin layer chromatography (HPTLC) was used for semi-quantitative analysis of ferulic acid and Z-ligustilide. Results: Small-scale household cultivation prevails and in Gansu—in contrast to Yunnan—the cultivation of dang gui is often the main income source of farmers. Farmers and dealers use size and odor of the root as main quality criteria. For Chinese medicine doctors, Gansu as the production area is the main criterion. Higher amounts of ferulic acid in plant material from Yunnan compared to Gansu were found. Additionally, a negative relation of root length with both ferulic acid and Z-ligustilide as well as head diameter with ferulic acid were found. Conclusions: HPTLC is a valid method for semi-quantitative analysis of the marker compounds of dang gui. However, the two main marker compounds cannot explain why size and smell of the root or production area are seen as quality criteria. This hints at the inherent difficulty to correlate quality notions of medicinal plants with specific chemical compounds. With respect to this, more attention should be paid to quality in terms of cultivation and processing techniques. View Full-Text
Keywords: Angelica sinensis; Chinese medicine; dang gui; ethnobotany; Gansu; medicinal plants; TCM; Yunnan Angelica sinensis; Chinese medicine; dang gui; ethnobotany; Gansu; medicinal plants; TCM; Yunnan
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Supplementary material

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Giacomelli, N.; Yongping, Y.; Huber, F.K.; Ankli, A.; Weckerle, C.S. Angelica sinensis (Oliv.) Diels: Influence of Value Chain on Quality Criteria and Marker Compounds Ferulic Acid and Z-Ligustilide. Medicines 2017, 4, 14.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Medicines EISSN 2305-6320 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top