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Medicines 2016, 3(4), 31; doi:10.3390/medicines3040031

Isolation and Cytotoxic Investigation of Flacourtin from Oncoba spinosa

Department of Chemistry, Obafemi Awolowo University, Ile-Ife 220005, Nigeria
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Author to whom correspondence should be addressed.
Academic Editor: James D. Adams
Received: 26 October 2016 / Revised: 23 November 2016 / Accepted: 29 November 2016 / Published: 6 December 2016
(This article belongs to the Special Issue Plant Medicines for Clinical Trial)
View Full-Text   |   Download PDF [415 KB, uploaded 6 December 2016]   |  

Abstract

Background: Oncoba spinosa, an endangered medicinal plant whose secondary metabolites have not been extensively profiled, and which is hitherto yet to be examined for cytotoxicity, is being investigated in this study. Methods: Leaves of Oncoba spinosa (800 g) were extracted with 95% aqueous methanol. The crude extract was partitioned with n-hexane and the resultant defatted extract was extensively chromatographed on silica gel to yield compound 1 which was subjected to spectroscopic analysis. A brine shrimps lethality test was used to establish the cytotoxicity potentials of the isolated compound and the plant extracts. Results: Compound 1 was elucidated as flacourtin, 3-hydroxy-4-hydroxymethylphenyl-6-O-benzoyl-β-d-glucopyranoside. The LD50 values obtained were less than 1000 µg/mL for flacourtin and the plant extracts. Conclusion: Flacourtin is being reported for the first time in the O. spinosa. The preliminary toxicity assay indicated that flacourtin and the plant extracts were not cytotoxic; thus, the tradomedicinal uses of the plant may portend no danger. View Full-Text
Keywords: Oncoba spinosa; Flacourtin; cytotoxicity; Flacourtiaceae; phenolic ester glycoside Oncoba spinosa; Flacourtin; cytotoxicity; Flacourtiaceae; phenolic ester glycoside
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    Description: NMR spectra

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Balogun, O.S.; Ajayi, O.S.; Lawal, O.S. Isolation and Cytotoxic Investigation of Flacourtin from Oncoba spinosa. Medicines 2016, 3, 31.

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