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Medicines 2016, 3(4), 28; doi:10.3390/medicines3040028

Antifungal and Anticancer Potential of Argemone mexicana L.

1
Department of Biotechnology, Dr. Babasaheb Ambedkar Marathwada University, Subcampus, Osmanabad 413501, Maharashtra, India
2
Department of Biotechnology, College of Computer Science and Information Technology, Latur 413512, Maharashtra, India
*
Author to whom correspondence should be addressed.
Academic Editors: Elizabeth Sommers and Sivarama Vinjamury
Received: 12 August 2016 / Revised: 15 October 2016 / Accepted: 28 October 2016 / Published: 3 November 2016
(This article belongs to the Special Issue Complementary and Alternative Medicine for Cancer Patients)
View Full-Text   |   Download PDF [2223 KB, uploaded 7 November 2016]   |  

Abstract

Background: Medicinal plants are widely used to treat infectious diseases, metabolic disorders and cancer. Argemone mexicana L. (A. mexicana), commonly found on desolate land of Marathwada (Maharashtra, India) has been used to treat oral cavity infections. Methods: In this study, cold aqueous and methanolic extracts were prepared from A. mexicana stem and leaves. These extracts were tested for their antifungal and anticancer activities. The antifungal activity was tested using the agar well diffusion method, while the anticancer activity against immortalized cell lines was assessed by trypan blue assay. Results: It was observed that both cold aqueous and methanolic extracts of A. mexicana stem and leaves inhibited the growth of Mucor indicus, Aspergillus flavus, Aspergillus niger and Penicillum notatum. Antifungal activity of the extract was comparable to that of Amphoterecin-B. A. mexicana extracts had a cytotoxic effect on A549, SiHa and KB immortalized cell lines that were similar to that of berberine. Conclusion: The A. mexicana leaf and stems exhibit strong antifungal and anticancer potential. View Full-Text
Keywords: Argemone mexicana; antifungal potential; cold aqueous and methanolic extract; trypan blue assay Argemone mexicana; antifungal potential; cold aqueous and methanolic extract; trypan blue assay
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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More, N.V.; Kharat, A.S. Antifungal and Anticancer Potential of Argemone mexicana L.. Medicines 2016, 3, 28.

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