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Medicines 2016, 3(1), 7; doi:10.3390/medicines3010007

Composition and Biological Activities of Murraya paniculata (L.) Jack Essential Oil from Nepal

1
Department of Chemistry, University of Alabama in Huntsville, Huntsville, AL 35899, USA
2
Department of Botany, Tribhuvan University, MMAMC, Biratnagar 56600, Nepal
*
Author to whom correspondence should be addressed.
Academic Editors: Lutfun Nahar, Norazah Basar and Satyajit D. Sarker
Received: 10 January 2016 / Revised: 4 February 2016 / Accepted: 16 February 2016 / Published: 26 February 2016
(This article belongs to the Special Issue Essential Oils: Chemistry and Bioactivity)
View Full-Text   |   Download PDF [660 KB, uploaded 26 February 2016]   |  

Abstract

Murraya paniculata (L.) Jack, a small tropical evergreen shrub growing in Nepal, has numerous uses in traditional medicine for treatment of abdominal pain, diarrhea, stomach ache, headache, edema, thrombosis, and blood stasis. The present study investigated the chemical composition and bioactivities of the leaf essential oil from M. paniculata from Nepal. The essential oil from leaves was obtained by hydrodistillation and a detailed chemical analysis was conducted by gas chromatography-mass spectrometry (GC-MS). The essential oil was screened for antimicrobial activity using the microbroth dilution test, for nematicidal activity against Caenorhabditis elegans, and for lethality against brine shrimp (Artemia salina). A total of 76 volatile components were identified from the essential oil. The major components were methyl palmitate (11.1%), isospathulenol (9.4%), (E,E)-geranyl linalool (5.3%), benzyl benzoate (4.2%), selin-6-en-4-ol (4.0%), β-caryophyllene (4.0%), germacrene B (3.6%), germacrene D (3.4%), and γ-elemene (3.2%). The essential oil showed no antibacterial activity, marginal antifungal activity against Aspergillus niger (MIC = 313 μg/mL), a moderate activity against A. salina (LC50 = 41 μg/mL), and a good nematicidal activity against C. elegans (LC50 = 37 μg/mL). View Full-Text
Keywords: Murraya paniculata; GC-MS; essential oil composition; hierarchical cluster analysis; antifungal; brine shrimp lethality; nematicidal Murraya paniculata; GC-MS; essential oil composition; hierarchical cluster analysis; antifungal; brine shrimp lethality; nematicidal
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MDPI and ACS Style

Dosoky, N.S.; Satyal, P.; Gautam, T.P.; Setzer, W.N. Composition and Biological Activities of Murraya paniculata (L.) Jack Essential Oil from Nepal. Medicines 2016, 3, 7.

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