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Medicines 2014, 1(1), 3-11; doi:10.3390/medicines1010003
Article

Comparison of Cultivars and Seasonal Variation in Blueberry (Vaccinium Species) Leaf Extract on Adult T-Cell Leukemia Cell Line Growth Suppression

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Received: 7 November 2013; in revised form: 20 January 2014 / Accepted: 31 March 2014 / Published: 30 June 2014
(This article belongs to the Special Issue Feature Papers)
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Abstract: The inhibitory effects of blueberry leaves on the proliferation of adult T-cell leukemia (ATL) cell lines have previously been reported. A comparison of blueberry leaf extracts from different cultivars and seasonal variation were investigated regarding their effects on ATL cell line proliferation. The inhibitory effects of 80% ethanol leaf extracts from different blueberry cultivars collected from April to December in 2006 or 2008 were evaluated using two ATL cell lines. The bioactivities of leaf extracts of rabbit-eye blueberry (Vaccinium virgatum Aiton; RB species), southern highbush blueberry (V. spp.; SB species), northern highbush blueberry (V. corymbosum L.; NB species), and wild blueberry (V. bracteatum Thunb.; WB species) were compared. Of these, leaves of the RB species collected in December showed a significantly stronger inhibitory effect in both cell lines than the SB, NB, or WB species. These results suggest elevated biosynthesis of ATL-preventative bioactive compounds in the leaves of the RB species before the defoliation season.
Keywords: adult T-cell leukemia; blueberry leaves; rabbit-eye blueberry; defoliation season; cell proliferation assay adult T-cell leukemia; blueberry leaves; rabbit-eye blueberry; defoliation season; cell proliferation assay
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Kai, H.; Fuse, T.; Kunitake, H.; Morishita, K.; Matsuno, K. Comparison of Cultivars and Seasonal Variation in Blueberry (Vaccinium Species) Leaf Extract on Adult T-Cell Leukemia Cell Line Growth Suppression. Medicines 2014, 1, 3-11.

AMA Style

Kai H, Fuse T, Kunitake H, Morishita K, Matsuno K. Comparison of Cultivars and Seasonal Variation in Blueberry (Vaccinium Species) Leaf Extract on Adult T-Cell Leukemia Cell Line Growth Suppression. Medicines. 2014; 1(1):3-11.

Chicago/Turabian Style

Kai, Hisahiro; Fuse, Takuichi; Kunitake, Hisato; Morishita, Kazuhiro; Matsuno, Koji. 2014. "Comparison of Cultivars and Seasonal Variation in Blueberry (Vaccinium Species) Leaf Extract on Adult T-Cell Leukemia Cell Line Growth Suppression." Medicines 1, no. 1: 3-11.

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