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Innovation in Medicine
Medicines 2014, 1(1), 3-11; doi:10.3390/medicines1010003
Article

Comparison of Cultivars and Seasonal Variation in Blueberry (Vaccinium Species) Leaf Extract on Adult T-Cell Leukemia Cell Line Growth Suppression

1,* , 2
,
2
,
3
 and
1
1 Department of Pharmaceutical Health Sciences, School of Pharmaceutical Sciences, Kyushu University of Health and Welfare, 1714-1 Yoshino-machi, Nobeoka, Miyazaki 882-8508, Japan 2 Department of Biochemistry and Applied Biosciences, Faculty of Agriculture, University of Miyazaki, 1-1 Gakuenkibanadai-nishi, Miyazaki 889-2192, Japan 3 Division of Tumor and Cellular Biochemistry, Department of Medical Sciences, Faculty of Medicine, University of Miyazaki, 5200 Kihara Kiyotake, Miyazaki, Miyazaki 889-1692, Japan
* Author to whom correspondence should be addressed.
Received: 7 November 2013 / Revised: 20 January 2014 / Accepted: 31 March 2014 / Published: 30 June 2014
(This article belongs to the Special Issue Feature Papers)
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Abstract

The inhibitory effects of blueberry leaves on the proliferation of adult T-cell leukemia (ATL) cell lines have previously been reported. A comparison of blueberry leaf extracts from different cultivars and seasonal variation were investigated regarding their effects on ATL cell line proliferation. The inhibitory effects of 80% ethanol leaf extracts from different blueberry cultivars collected from April to December in 2006 or 2008 were evaluated using two ATL cell lines. The bioactivities of leaf extracts of rabbit-eye blueberry (Vaccinium virgatum Aiton; RB species), southern highbush blueberry (V. spp.; SB species), northern highbush blueberry (V. corymbosum L.; NB species), and wild blueberry (V. bracteatum Thunb.; WB species) were compared. Of these, leaves of the RB species collected in December showed a significantly stronger inhibitory effect in both cell lines than the SB, NB, or WB species. These results suggest elevated biosynthesis of ATL-preventative bioactive compounds in the leaves of the RB species before the defoliation season.
Keywords: adult T-cell leukemia; blueberry leaves; rabbit-eye blueberry; defoliation season; cell proliferation assay adult T-cell leukemia; blueberry leaves; rabbit-eye blueberry; defoliation season; cell proliferation assay
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
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Kai, H.; Fuse, T.; Kunitake, H.; Morishita, K.; Matsuno, K. Comparison of Cultivars and Seasonal Variation in Blueberry (Vaccinium Species) Leaf Extract on Adult T-Cell Leukemia Cell Line Growth Suppression. Medicines 2014, 1, 3-11.

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