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Inorganics 2015, 3(4), 516-533; doi:10.3390/inorganics3040516

Gadolinium(III)-DOTA Complex Functionalized with BODIPY as a Potential Bimodal Contrast Agent for MRI and Optical Imaging

Department of Chemistry, KU Leuven, Celestijnenlaan 200F, Leuven 3001, Belgium
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Academic Editors: Stephen Mansell and Steve Liddle
Received: 29 September 2015 / Revised: 10 November 2015 / Accepted: 17 November 2015 / Published: 25 November 2015
(This article belongs to the Special Issue Rare Earth and Actinide Complexes)
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Abstract

The synthesis and characterization of a novel gadolinium(III) DOTA complex functionalized with a boron-dipyrromethene derivative (BODIPY) is described. The assembly of the complex relies on azide diazotransfer chemistry in a copper tube flow reactor. The azide thus formed is coupled directly with an alkyne via click chemistry, resulting into a paramagnetic and luminescent gadolinium(III) complex. Luminescent data and relaxometric properties of the complex have been evaluated, suggesting the potential applicability of the complexes as a bimodal contrast agent for magnetic resonance and optical imaging. The complex displays a bright emission at 523 nm with an absorption maximum of 507 nm and high quantum yields of up to 83% in water. The proton relaxivity of the complex measured at 310 K and at frequencies of 20 and 60 MHz had the values of 3.9 and 3.6 s1·mM1, respectively. View Full-Text
Keywords: Gadolinium(III); BODIPY; click chemistry; MRI; contrast agent Gadolinium(III); BODIPY; click chemistry; MRI; contrast agent
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Ceulemans, M.; Nuyts, K.; De Borggraeve, W.M.; Parac-Vogt, T.N. Gadolinium(III)-DOTA Complex Functionalized with BODIPY as a Potential Bimodal Contrast Agent for MRI and Optical Imaging. Inorganics 2015, 3, 516-533.

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