Genetic Predisposition to Neuroblastoma
AbstractNeuroblastoma is the most common solid tumor in children under the age of one. It displays remarkable phenotypic heterogeneity, resulting in differences in outcomes that correlate with clinical and biologic features at diagnosis. While neuroblastoma accounts for approximately 5% of all cancer diagnoses in pediatrics, it disproportionately results in about 9% of all childhood deaths. Research advances over the decades have led to an improved understanding of neuroblastoma biology. However, the initiating events that lead to the development of neuroblastoma remain to be fully elucidated. It has only been recently that advances in genetics and genomics have allowed researchers to unravel the predisposing factors enabling the development of neuroblastoma and fully appreciate the interplay between the genetics of tumor and host. In this review, we outline the current understanding of familial neuroblastoma and highlight germline variations that predispose children to sporadic disease. We also discuss promising future directions in neuroblastoma genomic research and potential clinical applications for these advances. View Full-Text
Share & Cite This Article
Barr, E.K.; Applebaum, M.A. Genetic Predisposition to Neuroblastoma. Children 2018, 5, 119.
Barr EK, Applebaum MA. Genetic Predisposition to Neuroblastoma. Children. 2018; 5(9):119.Chicago/Turabian Style
Barr, Erin K.; Applebaum, Mark A. 2018. "Genetic Predisposition to Neuroblastoma." Children 5, no. 9: 119.
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.