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Children 2018, 5(8), 107; https://doi.org/10.3390/children5080107

Late Effects and Survivorship Issues in Patients with Neuroblastoma

1
Department of Pediatrics, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA
2
Department of Pediatrics, Weill Cornell Medical College, New York, NY 10065, USA
3
Department of Pediatrics, Comer Children’s Hospital, University of Chicago, Chicago, IL 60637, USA
*
Author to whom correspondence should be addressed.
Received: 29 June 2018 / Revised: 27 July 2018 / Accepted: 1 August 2018 / Published: 6 August 2018
(This article belongs to the Special Issue Recent Advances in Diagnosis and Treatment of Neuroblastoma)
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Abstract

Over the past two decades, marked progress has been made in understanding the biology of neuroblastoma; this has led to refined risk stratification and treatment modifications with resultant increasing 5-year survival rates for children with neuroblastoma. Survivors, however, remain at risk for a wide variety of potential treatment-related complications, or “late effects”, which may lead to excess morbidity and premature mortality in this cohort. This review summarizes the existing survivorship literature on long-term health outcomes for survivors of neuroblastoma, focusing specifically on potential injury to the endocrine, sensory, cardiovascular, pulmonary, and renal systems, as well as survivors’ treatment-related risk for subsequent neoplasms and impaired quality of life. Additional work is needed to assess the potential late effects of newer multimodality therapies with the aim of optimizing long-term medical and psychosocial outcomes for all survivors of neuroblastoma. View Full-Text
Keywords: neuroblastoma; late effects; childhood cancer; survivorship neuroblastoma; late effects; childhood cancer; survivorship
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Friedman, D.N.; Henderson, T.O. Late Effects and Survivorship Issues in Patients with Neuroblastoma. Children 2018, 5, 107.

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