Late Effects and Survivorship Issues in Patients with Neuroblastoma
AbstractOver the past two decades, marked progress has been made in understanding the biology of neuroblastoma; this has led to refined risk stratification and treatment modifications with resultant increasing 5-year survival rates for children with neuroblastoma. Survivors, however, remain at risk for a wide variety of potential treatment-related complications, or “late effects”, which may lead to excess morbidity and premature mortality in this cohort. This review summarizes the existing survivorship literature on long-term health outcomes for survivors of neuroblastoma, focusing specifically on potential injury to the endocrine, sensory, cardiovascular, pulmonary, and renal systems, as well as survivors’ treatment-related risk for subsequent neoplasms and impaired quality of life. Additional work is needed to assess the potential late effects of newer multimodality therapies with the aim of optimizing long-term medical and psychosocial outcomes for all survivors of neuroblastoma. View Full-Text
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Friedman, D.N.; Henderson, T.O. Late Effects and Survivorship Issues in Patients with Neuroblastoma. Children 2018, 5, 107.
Friedman DN, Henderson TO. Late Effects and Survivorship Issues in Patients with Neuroblastoma. Children. 2018; 5(8):107.Chicago/Turabian Style
Friedman, Danielle N.; Henderson, Tara O. 2018. "Late Effects and Survivorship Issues in Patients with Neuroblastoma." Children 5, no. 8: 107.
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