Clinical Profile Associated with Adverse Childhood Experiences: The Advent of Nervous System Dysregulation
AbstractBackground: We report the prevalence of children with multiple medical symptoms in a pediatric neurology clinic, describe their symptom profiles, and explore their association with adverse childhood experiences (ACEs). Methods: We retrospectively reviewed 100 consecutive patients from an outpatient pediatric neurology clinic. Patients were included if they were ≥5 years old and reported ≥4 symptoms that were unexplained for ≥3-months. Symptom profiles across six functional domains were recorded: (1) executive dysfunction, (2) sleep disturbances, (3) autonomic dysregulation, (4) somatization, (5) digestive symptoms, and (6) emotional dysregulation. ACEs were scored for all patients. Results: Seventeen patients reported ≥4 medical symptoms. Somatization, sleep disturbances, and emotional dysregulation occurred in 100% patients, with executive dysfunction (94%), autonomic dysregulation (76%), and digestive problems (71%) in the majority. Forty-two children reported ≥1 ACE, but children with ≥4 symptoms were more likely to report ACEs compared to other children (88% vs. 33%; p < 0.0001) and had a higher median total ACE score (3 vs. 1; p < 0.001). Conclusions: Children with multiple medical symptoms should be screened for potential exposure to ACEs. A clinical profile of symptoms across multiple functional domains suggests putative neurobiological mechanisms involving stress and nervous system dysregulation that require further study. View Full-Text
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Elbers, J.; Rovnaghi, C.R.; Golianu, B.; Anand, K.J.S. Clinical Profile Associated with Adverse Childhood Experiences: The Advent of Nervous System Dysregulation. Children 2017, 4, 98.
Elbers J, Rovnaghi CR, Golianu B, Anand KJS. Clinical Profile Associated with Adverse Childhood Experiences: The Advent of Nervous System Dysregulation. Children. 2017; 4(11):98.Chicago/Turabian Style
Elbers, Jorina; Rovnaghi, Cynthia R.; Golianu, Brenda; Anand, Kanwaljeet J.S. 2017. "Clinical Profile Associated with Adverse Childhood Experiences: The Advent of Nervous System Dysregulation." Children 4, no. 11: 98.
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