Next Article in Journal / Special Issue
Complementary Approaches to Existing Target Based Drug Discovery for Identifying Novel Drug Targets
Previous Article in Journal / Special Issue
Personalized Dosimetry for Radionuclide Therapy Using Molecular Imaging Tools
Article Menu

Export Article

Open AccessReview
Biomedicines 2016, 4(4), 26; doi:10.3390/biomedicines4040026

The Strategies to Homogenize PET/CT Metrics: The Case of Onco-Haematological Clinical Trials

Medical Physics Unit, Santa Croce e Carle Hospital, Cuneo 12100, Italy
*
Author to whom correspondence should be addressed.
Academic Editor: Benjamin Franc
Received: 3 September 2016 / Revised: 6 November 2016 / Accepted: 8 November 2016 / Published: 15 November 2016
(This article belongs to the Special Issue Molecular Imaging as a Tool for Personalized Medicine)
View Full-Text   |   Download PDF [1654 KB, uploaded 15 November 2016]   |  

Abstract

Positron emission tomography (PET) has been a widely used tool in oncology for staging lymphomas for a long time. Recently, several large clinical trials demonstrated its utility in therapy management during treatment, paving the way to personalized medicine. In doing so, the traditional way of reporting PET based on the extent of disease has been complemented by a discrete scale that takes in account tumour metabolism. However, due to several technical, physical and biological limitations in the use of PET uptake as a biomarker, stringent rules have been used in clinical trials to reduce the errors in its evaluation. Within this manuscript we will describe shortly the evolution in PET reporting, examine the main errors in uptake measurement, and analyse which strategy the clinical trials applied to reduce them. View Full-Text
Keywords: positron emission tomography; standardization; clinical trials; biomarker; standardized uptake value; lymphoma positron emission tomography; standardization; clinical trials; biomarker; standardized uptake value; lymphoma
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Chauvie, S.; Bergesio, F. The Strategies to Homogenize PET/CT Metrics: The Case of Onco-Haematological Clinical Trials. Biomedicines 2016, 4, 26.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Biomedicines EISSN 2227-9059 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top