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Biomedicines 2016, 4(2), 11; doi:10.3390/biomedicines4020011

Recent Innovations in Peptide Based Targeted Drug Delivery to Cancer Cells

1
Department of Chemical Sciences, Ariel University, Ariel 40700, Israel
2
Department of Chemical Engineering and Biotechnology, Ariel University, Ariel 40700, Israel
*
Author to whom correspondence should be addressed.
Academic Editor: Kenneth Cornetta
Received: 21 April 2016 / Revised: 16 May 2016 / Accepted: 23 May 2016 / Published: 26 May 2016
View Full-Text   |   Download PDF [564 KB, uploaded 26 May 2016]   |  

Abstract

Targeted delivery of chemotherapeutics and diagnostic agents conjugated to carrier ligands has made significant progress in recent years, both in regards to the structural design of the conjugates and their biological effectiveness. The goal of targeting specific cell surface receptors through structural compatibility has encouraged the use of peptides as highly specific carriers as short peptides are usually non-antigenic, are structurally simple and synthetically diverse. Recent years have seen many developments in the field of peptide based drug conjugates (PDCs), particularly for cancer therapy, as their use aims to bypass off-target side-effects, reducing the morbidity common to conventional chemotherapy. However, no PDCs have as yet obtained regulatory approval. In this review, we describe the evolution of the peptide-based strategy for targeted delivery of chemotherapeutics and discuss recent innovations in the arena that should lead in the near future to their clinical application. View Full-Text
Keywords: targeted drug delivery; therapeutic carriers; peptide–drug conjugates; cancer therapy; cancer imaging targeted drug delivery; therapeutic carriers; peptide–drug conjugates; cancer therapy; cancer imaging
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Gilad, Y.; Firer, M.; Gellerman, G. Recent Innovations in Peptide Based Targeted Drug Delivery to Cancer Cells. Biomedicines 2016, 4, 11.

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