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Biomedicines 2016, 4(1), 7; doi:10.3390/biomedicines4010007

Innate Lymphoid Cells in Tumor Immunity

1
Department of Tumor Immunology, Radboud University Medical Center, Radboud Institute for Molecular Life Sciences, 6525 GA Nijmegen, The Netherlands
2
Department of Medical Oncology, Radboud University Medical Center, Radboud Institute for Molecular Life Sciences, 6525 GA Nijmegen, The Netherlands
*
Author to whom correspondence should be addressed.
Academic Editor: Vincenzo Cerullo
Received: 23 December 2015 / Revised: 5 February 2016 / Accepted: 15 February 2016 / Published: 25 February 2016
(This article belongs to the Special Issue Dendritic Cells and Cancer Immunotherapy)
View Full-Text   |   Download PDF [615 KB, uploaded 25 February 2016]   |  

Abstract

Innate lymphoid cells (ILCs) are a group of immune cells of the lymphoid lineage that do not possess antigen specificity. The group includes natural killer (NK) cells, lymphoid tissue inducer (LTi) cells and the recently identified ILC1s, ILC2s and ILC3s. Although the role of NK cells in the context of cancer has been well established, the involvement of other ILC subsets in cancer progression and resistance is just emerging. Here, we review the literature on the role of the different ILC subsets in tumor immunity and discuss its implications for cancer treatment and monitoring. View Full-Text
Keywords: innate lymphoid cells (ILCs); ILC1s; ILC2s; ILC3s; lymphoid tissue inducer (LTi) cells; cancer; cancer immunotherapy innate lymphoid cells (ILCs); ILC1s; ILC2s; ILC3s; lymphoid tissue inducer (LTi) cells; cancer; cancer immunotherapy
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

van Beek, J.J.P.; Martens, A.W.J.; Bakdash, G.; de Vries, I.J.M. Innate Lymphoid Cells in Tumor Immunity. Biomedicines 2016, 4, 7.

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