Next Article in Journal / Special Issue
Challenges and Prospects for Helper-Dependent Adenoviral Vector-Mediated Gene Therapy
Previous Article in Journal / Special Issue
Gulonolactone Addition to Human Hepatocellular Carcinoma Cells with Gene Transfer of Gulonolactone Oxidase Restores Ascorbate Biosynthesis and Reduces Hypoxia Inducible Factor 1
Biomedicines 2014, 2(1), 110-131; doi:10.3390/biomedicines2010110
Review

Feasibility of Applying Helper-Dependent Adenoviral Vectors for Cancer Immunotherapy

 and
*
Received: 20 December 2013 / Revised: 25 February 2014 / Accepted: 26 February 2014 / Published: 10 March 2014
(This article belongs to the Special Issue Gene Therapy Used in Cancer Treatment)
View Full-Text   |   Download PDF [742 KB, 12 March 2014; original version 10 March 2014]   |   Browse Figures

Abstract

Adenoviruses (Ads) infect a broad range of tissue types, and derived vectors have been extensively used for gene therapy. Helper-dependent Ad vectors (HDAds), devoid of viral coding sequences, allow for insertion of large or multiple transgenes in a single vector and have been preclinically used for the study of genetic disorders. However, the clinical application of Ad vectors including HDAds for genetic disorders has been hampered by an acute toxic response. This characteristic, while disadvantageous for gene replacement therapy, could be strategically advantageous for the activation of an immune response if HDAds were used as an adjunct treatment in cancer. Cancer treatments including immunotherapy are frequently limited by the inhibitory environment produced by both tumors and their stroma, each of which express numerous inhibitory molecules. Hence, multiple inhibitory mechanisms must be overcome for development of anti-tumor immunity. The large coding capacity of HDAds can accommodate multiple immune modulating transgenes that could produce a combined effect to overcome tumor-derived inhibition and ensure intratumoral effector T-cell proliferation and function. In this review, we discuss the potential advantages of HDAds to cancer immunotherapy based on potent host immune responses to Ads.
Keywords: Helper-dependent adenoviral vector; immune response; pattern-recognition receptor; cancer immunotherapy Helper-dependent adenoviral vector; immune response; pattern-recognition receptor; cancer immunotherapy
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Share & Cite This Article

Further Mendeley | CiteULike
Export to BibTeX |
EndNote
MDPI and ACS Style

Farzad, L.M.; Suzuki, M. Feasibility of Applying Helper-Dependent Adenoviral Vectors for Cancer Immunotherapy. Biomedicines 2014, 2, 110-131.

View more citation formats

Related Articles

Article Metrics

Comments

Cited By

[Return to top]
Biomedicines EISSN 2227-9059 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert