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Pharmacy 2015, 3(4), 379-385; doi:10.3390/pharmacy3040379

Stability of Fentanyl Citrate, Hydromorphone Hydrochloride, Ketamine Hydrochloride, Midazolam, Morphine Sulfate, and Pentobarbital Sodium in Polypropylene Syringes

Primary Children’s Hospital, 100 Mario Capecchi Dr., Salt Lake City, UT 84113, USA
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Author to whom correspondence should be addressed.
Academic Editor: Keith A. Wilson
Received: 22 October 2015 / Revised: 30 November 2015 / Accepted: 10 December 2015 / Published: 16 December 2015
View Full-Text   |   Download PDF [370 KB, uploaded 16 December 2015]

Abstract

Purpose: Determine the stability of fentanyl 10 mcg/mL in 0.9% sodium chloride, fentanyl 10 mcg/mL in 5% dextrose, fentanyl 50 mcg/mL, hydromorphone 100 mcg/mL in 0.9% sodium chloride, ketamine 10 mg/mL, midazolam 0.4 mg/mL in 5% dextrose, midazolam 5 mg/mL, morphine 1 mg/mL in 0.9% sodium chloride, morphine 1 mg/mL in 5% dextrose, and pentobarbital 50 mg/mL when stored as single drug entities at room temperature in polypropylene syringes. Methods: Four 5 mL samples of each drug and concentration were prepared in 10 mL polypropylene syringes. The samples were stored at ambient room temperature in a locked cabinet. Triplicate determinations of drug concentration for each sample were performed initially, on day 50 or 51, and on day 100 using high-performance liquid chromatography with diode-array detection. Results: With the exception of the hydromorphone 100 mcg/mL dilution, all compounds were found to contain greater than 95% of their initial concentration remaining at 100 days. Each sample remained clear and colorless when visually inspected. View Full-Text
Keywords: stability; pharmacy; fentanyl; hydromorphone; ketamine; midazolam; morphine; pentobarbital stability; pharmacy; fentanyl; hydromorphone; ketamine; midazolam; morphine; pentobarbital
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Anderson, C.; MacKay, M. Stability of Fentanyl Citrate, Hydromorphone Hydrochloride, Ketamine Hydrochloride, Midazolam, Morphine Sulfate, and Pentobarbital Sodium in Polypropylene Syringes. Pharmacy 2015, 3, 379-385.

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