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Sci. Pharm. 2017, 85(1), 9; doi:10.3390/scipharm85010009

Serum Cystatin C as a Biomarker in Diffuse Large B-Cell Lymphoma

Department of Biochemistry, Faculty of Pharmacy, Mansoura University, Mansoura 35516, Egypt
Oncology Center, Faculty of Medicine, Mansoura University, Mansoura 35516, Egypt
Author to whom correspondence should be addressed.
Academic Editor: Gernot Eller
Received: 22 October 2016 / Revised: 28 February 2017 / Accepted: 28 February 2017 / Published: 8 March 2017
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Elevated serum levels of cystatin C are found to be related to poor outcome and metastatic potential of some malignant disorders. To evaluate the clinical prominence of serum cystatin C in diffuse large B-cell lymphoma (DLBCL), blood samples were obtained from 58 patients at the time of diagnosis and paired blood samples were obtained from 22 patients at the time of remission. Also, serum cystatin C level was measured in matched healthy controls. Serum cystatin C levels were significantly more elevated in DLBCL patients than in controls (p < 0.0001). Furthermore, paired-sample analysis revealed that pretreatment cystatin C levels were reduced significantly in patients who achieved remission after therapy (p = 0.016). High serum cystatin C levels were correlated with age over 60 years (p = 0.049), extra-nodal involvement (p = 0.005) and with high serum lactate dehydrogenase (LDH) (p < 0.013). Elevated serum cystatin C levels were associated with extra-nodal involvement and they were significantly reduced to normal range after the remission. However, Kaplan–Meier curves revealed no survival difference in the pretreatment serum cystatin C levels. Therefore, serum cystatin C may be a novel biomarker that reflects tumor burden in DLBCL but bears no prognostic significance regarding survival. View Full-Text
Keywords: diffuse large B-cell lymphoma; cystatin C; survival; extra-nodal involvement diffuse large B-cell lymphoma; cystatin C; survival; extra-nodal involvement

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Hammouda, N.E.; Salah El-Din, M.A.; El-Shishtawy, M.M.; El-Gayar, A.M. Serum Cystatin C as a Biomarker in Diffuse Large B-Cell Lymphoma. Sci. Pharm. 2017, 85, 9.

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