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Sci. Pharm. 2017, 85(1), 7; doi:10.3390/scipharm85010007

Antimutagenic Activity of Ethanol Extract of Rhaphidophora pinnata (L.f) Schott Leaves on Mice

1
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Sumatera Utara, Tri Dharma Street, No.5, Medan 20155, Indonesia
2
Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Sumatera Utara, Tri Dharma Street, No.5, Medan 20155, Indonesia
3
Department of Pharmacology, Faculty of Pharmacy, University of Sumatera Utara, Tri Dharma Street, No.5, Medan 20155, Indonesia
*
Author to whom correspondence should be addressed.
Academic Editor: Gernot Eller
Received: 22 December 2016 / Revised: 7 February 2017 / Accepted: 2 February 2017 / Published: 17 February 2017
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Abstract

Rhaphidophora pinnata is suggested to prevent or treat cancer of genetic mutations. In this study, antimutagenic activity of an ethanol extract of Rhaphidophora pinnata leaves was evaluated by using a bone marrow micronucleus assay on mice. Male mice (20–30 g) were treated for sevendays with an ethanol extract of Rhaphidophora pinnata leaves at a dose of 500, 750 and 1000 mg/kg/day/orally, prior to exposure to cyclophosphamide (i.p. 30 mg/kg), 24 h after the end of the treatment. Antimutagenic activity was determined by the decrease of micronuclei (MN). The results showed that a single administration of all variant doses of the extract had significantly decreased the micronucleus formation in bone marrow cell of mice as compared to the cyclophosphamide group. The ethanol extract of Rhaphidophora pinnata leaves had antimutagenic activity against cyclophosphamide-induced gene mutation. View Full-Text
Keywords: Antimutagenic activity; ethanol extract; Rhaphidophora pinnata leaves Antimutagenic activity; ethanol extract; Rhaphidophora pinnata leaves
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Masfria; Sumaiyah; Dalimunthe, A. Antimutagenic Activity of Ethanol Extract of Rhaphidophora pinnata (L.f) Schott Leaves on Mice. Sci. Pharm. 2017, 85, 7.

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