Next Article in Journal
Synthesis, Photochemical and Photoinduced Antibacterial Activity Studies of meso-Tetra(pyren-1-yl)porphyrin and its Ni, Cu and Zn Complexes
Previous Article in Journal
Formulation, Characterisation, and in Vitro Skin Diffusion of Nanostructured Lipid Carriers for Deoxyarbutin Compared to a Nanoemulsion and Conventional Cream
Article Menu

Export Article

Open AccessArticle
Sci. Pharm. 2016, 84(4), 646-653; doi:10.3390/scipharm84040646

Evaluation of Certain Pharmaceutical Quality Attributes of Lisinopril Split Tablets

1
Pharmaceutical Sciences Unit, College of Pharmacy, Al Ain University of Science and Technology, P.O. Box 64141 Al Ain, UAE
2
Department of Pharmaceutics, College of Pharmacy and Health Sciences, Ajman University of Sciences and Technology, P.O. Box 346 Ajman, UAE
*
Author to whom correspondence should be addressed.
Academic Editor: Franz Gabor
Received: 10 March 2016 / Accepted: 28 July 2016 / Published: 11 October 2016
View Full-Text   |   Download PDF [850 KB, uploaded 11 October 2016]   |  

Abstract

Tablet splitting is an accepted practice for the administration of drugs for a variety of reasons, including dose adjustment, ease of swallowing and cost savings. The purpose of this study was to evaluate the physical properties of lisinopril tablets as a result of splitting the tablets either by hand or with a splitting device. The impact of the splitting technique of lisinopril (Zestril® tablets, 20 mg) on certain physical parameters such as weight variation, friability, disintegration, dissolution and drug content were studied. Splitting the tablets either by hand or with a splitter resulted in a minute but statistically significant average weight loss of <0.25% of the tablet to the surrounding environment. The variability in the weight of the hand-split tablet halves was more pronounced (37 out of 40 tablet halves varied by more than 10% from the mean weight) than when using the tablet splitter (3 out of 40 tablet halves). The dissolution and drug content of the hand-split tablets were therefore affected because of weight differences. However, the pharmacopoeia requirements for friability and disintegration time were met. Hand splitting of tablets can result in an inaccurate dose and may present clinical safety issues, especially for drugs with a narrow therapeutic window in which large fluctuations in drug concentrations are undesirable. It is recommended to use tablets with the exact desired dose, but if this is not an option, then a tablet splitter could be used. View Full-Text
Keywords: tablet splitting; lisinopril; weight variation; disintegration; dissolution spectrophotometric analysis tablet splitting; lisinopril; weight variation; disintegration; dissolution spectrophotometric analysis
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Fahelelbom, K.M.S.; Al-Tabakha, M.M.M.; Eissa, N.A.M.; Javadi, J. Evaluation of Certain Pharmaceutical Quality Attributes of Lisinopril Split Tablets. Sci. Pharm. 2016, 84, 646-653.

Show more citation formats Show less citations formats

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Sci. Pharm. EISSN 2218-0532 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top