Effect of Aromatic Substitution of Curcumin Nanoformulations on Their Stability
AbstractCurcumin, a poorly water-soluble bioactive compound, was successfully loaded into three different aromatic contents of hydroxypropylmethacrylamide (HPMA)-based polymeric micelles in order to develop water-soluble curcumin nanoformulations (Cur-Nano). The stability study of Cur-Nano was done by keeping the formulations at 4, 30, and 40 °C for 90 days. The physical appearance, curcumin remaining, and particle size of Cur-Nano were examined by visual inspection, high-performance liquid chromatography, and dynamic light scattering, respectively. After the storage period, the Cur-Nano composed of 100% aromatic-substituted polymer exhibited the highest stability of curcumin (80% of curcumin remaining) with a similar particle size as measured on the first day (50–60 nm) in all storage conditions. Curcumin in Cur-Nano composed of 25% and 0% aromatic-substituted polymer was significantly less stable accordingly. The results suggested that aromatic substitution to HPMA-based polymeric micelles can significantly enhance the stability of the loaded curcumin, considerably due to the π-π stacking interactions between the aromatic groups of curcumin and the polymer. It is concluded that curcumin-loaded polymeric micelles with high substituted aromatic content can be promising candidates with good storage stability for further clinical evaluations. View Full-Text
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Okonogi, S.; Naksuriya, O.; Charumanee, S.; Sirithunyalug, J. Effect of Aromatic Substitution of Curcumin Nanoformulations on Their Stability. Sci. Pharm. 2016, 84, 625-633.
Okonogi S, Naksuriya O, Charumanee S, Sirithunyalug J. Effect of Aromatic Substitution of Curcumin Nanoformulations on Their Stability. Scientia Pharmaceutica. 2016; 84(4):625-633.Chicago/Turabian Style
Okonogi, Siriporn; Naksuriya, Ornchuma; Charumanee, Suporn; Sirithunyalug, Jakkapan. 2016. "Effect of Aromatic Substitution of Curcumin Nanoformulations on Their Stability." Sci. Pharm. 84, no. 4: 625-633.