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Sci. Pharm. 2016, 84(3), 547-554; doi:10.3390/scipharm84030547

In Vivo Anticonvulsant Activity of Extracts and Protopine from the Fumaria schleicheri Herb

1
Department of Drugs Quality, Standardization and Certification, Institute of Pharmacy Professionals Qualification Improvement, National University of Pharmacy, Pushkinska 53, Kharkiv 61002, Ukraine
2
Department of Pharmacology, National University of Pharmacy, Pushkinska 53, Kharkiv 61002, Ukraine
3
Department of Pharmaceutical Chemistry, National University of Pharmacy, Pushkinska 53, Kharkiv 61002, Ukraine
*
Authors to whom correspondence should be addressed.
Academic Editor: Reinhard Länger
Received: 6 September 2015 / Accepted: 6 December 2015 / Published: 6 December 2015
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Abstract

The present study aimed to investigate the role of several biologically active compounds from Fumaria schleicheri Soy.-Will. in anticonvulsant models. The flavonoid fraction, alkaloid fraction, individual alkaloid protopine, and polysaccharide-protein complex were isolated from the Fumaria schleicheri herb and studied along with Fumaria schleicheri dry extract in mice with pentylenetetrazole-induced seizures. According to empirical results, the expressed anticonvulsant effect of Fumaria schleicheri dry extract depends on the synergism of biologically active compounds in herbal medicine, although some individual substances (mostly protopine and the protein-polysaccharide fraction) have shown moderate anti-seizure activity. View Full-Text
Keywords: Fumaria schleicheri; anticonvulsant activity; flavonoid fraction; alkaloid fraction; protopine; protein-polysaccharide fraction Fumaria schleicheri; anticonvulsant activity; flavonoid fraction; alkaloid fraction; protopine; protein-polysaccharide fraction
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Prokopenko, Y.; Tsyvunin, V.; Shtrygol’, S.; Georgiyants, V. In Vivo Anticonvulsant Activity of Extracts and Protopine from the Fumaria schleicheri Herb. Sci. Pharm. 2016, 84, 547-554.

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