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Sci. Pharm. 2016, 84(2), 379-392; doi:10.3797/scipharm.1505-15

Enhanced Permeation of Antiemetic Drug from Buccoadhesive Tablets by Using Bile Salts as Permeation Enhancers: Formulation characterization, In Vitro and Ex Vivo Studies

Department of Pharmaceutical Sciences, Mohanlal Sukhadia University, Main University Campus, Udaipur, Rajasthan, 313001, India
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Received: 19 May 2015 / Accepted: 29 July 2015 / Published: 29 July 2015
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Abstract

Buccal bioadhesive bilayer tablets of prochlorperazine maleate were designed and formulated by using buccoadhesive polymers such as hydroxypropylmethyl cellulose, Carbopol 934P, and sodium alginate. Physicochemical characteristics like the uniformity of weight, hardness, thickness, surface pH, drug content, swelling index, microenvironment pH, in vitro drug release, and in vivo buccoadhesion time of the prepared tablets were found to be dependent on the type and composition of the buccoadhesive materials used. The effect of bile salts on the permeation was studied through porcine buccal mucosa and it was found that out of three bile salts incorporated (sodium glycholate, sodium taurocholate, and sodium deoxycholate), sodium glycholate enhanced the permeation rate of prochlorperazine maleate by an enhancement factor of 1.37.
Keywords: Buccal tablet; Ex vivo; Antiemetic; Prochlorperazine; Bile salts Buccal tablet; Ex vivo; Antiemetic; Prochlorperazine; Bile salts
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

JAIN, C.P.; JOSHI, G.; KATARIA, U.; PATEL, K. Enhanced Permeation of Antiemetic Drug from Buccoadhesive Tablets by Using Bile Salts as Permeation Enhancers: Formulation characterization, In Vitro and Ex Vivo Studies. Sci. Pharm. 2016, 84, 379-392.

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