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Sci. Pharm. 2016, 84(1), 73-79; doi:10.3797/scipharm.1506-03

Criteria for Drug Pricing: Preliminary Experiences with Modeling the Price-Volume Relationship

HTA Unit, Regional Health Service, ESTAR, via San Salvi 12, 50135 Firenze, Italy.
Received: 11 June 2015 / Accepted: 27 August 2015 / Published: 27 August 2015
Download PDF [169 KB, uploaded 6 September 2016]


In managing drug prices at the national level, price-volume agreements are a tool aimed at ensuring sustainability in cases where the drug price is high and the population is large. These agreements in fact determine a progressive price reduction as more and more patients are treated. Price decays in this context generally have a purely empirical nature, but a theoretical basis would be needed.
The present paper describes a simple model that manages price-volume agreements. Two real examples (ranibizumab for macular degeneration and sofosbuvir for hepatitis C) are analysed in detail. The objective of our analysis was to identify some objective criteria to rationally guide these agreements and to convert these criteria into explicit quantitative rules.
Keywords: Price-volume agreements; Sofosbuvir; Ranibizumab Price-volume agreements; Sofosbuvir; Ranibizumab
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MESSORI, A. Criteria for Drug Pricing: Preliminary Experiences with Modeling the Price-Volume Relationship. Sci. Pharm. 2016, 84, 73-79.

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