Next Article in Journal
Pharmacokinetic Parameters Determination and In VitroIn Vivo Correlation of Ileocolonic-Targeted pH-Responsive Coated Mini-Tablets of Naproxen
Previous Article in Journal
Characterization of Oxidative Degradation Product of Darunavir by LC-MS/MS
Article Menu

Article Versions

Export Article

Open AccessArticle
Sci. Pharm. 2015, 83(4), 635-644; doi:10.3797/scipharm.1504-04

Effects of Methyl Jasmonate on Acute Stress Responses in Mice Subjected to Forced Swim and Anoxic Tests

Department of Pharmacology and Therapeutics, College of Medicine, University of Ibadan, Ibadan, Nigeria
*
Author to whom correspondence should be addressed.
Received: 7 April 2015 / Accepted: 11 June 2015 / Published: 11 June 2015
Download PDF [129 KB, uploaded 8 September 2016]

Abstract

Methyl jasmonate (MJ) is an anti-stress hormone released by plants in response to external stressors and aids adaptation to stress. In this study, we evaluated the anti-stress activity of MJ using the forced swim endurance test (FSET) and anoxic tolerance test in mice. Male Swiss mice were given MJ (25-100 mg/kg, i.p) 30 min before the FSET and anoxic test were carried out. The first occurrence of immobility, duration of immobility, time spent in active swimming, and latency to exhaustion were assessed in the FSET. The onset to anoxic convulsion was measured in the anoxic tolerance test. MJ significantly (p < 0.05) delayed the first occurrence of immobility and shortened the period of immobility, which indicates anti-stress property. MJ also increased the time spent in active swimming and prolonged the latency to exhaustion, which further suggests anti-stress activity. In addition, it also exhibited anti-stress property as evidenced by prolonged latency to first appearance of anoxic convulsions. The results of this study suggest that MJ demonstrated anti-stress activity and may be useful as an energizer in times of body weakness or exhaustion. Although more studies are necessary before concluding on how MJ exerts its anti-stress activity, the present data suggest an action similar to adaptogens in boosting energy and resilience in the face of stress.
Keywords: Methyl jasmonate; Forced swim endurance test; Anoxic tolerance test; Adaptogen Methyl jasmonate; Forced swim endurance test; Anoxic tolerance test; Adaptogen
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

ALUKO, O.M.; UMUKORO, S.; ANNAFI, O.S.; ADEWOLE, F.A.; OMOROGBE, O. Effects of Methyl Jasmonate on Acute Stress Responses in Mice Subjected to Forced Swim and Anoxic Tests. Sci. Pharm. 2015, 83, 635-644.

Show more citation formats Show less citations formats

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Sci. Pharm. EISSN 2218-0532 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top