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Sci. Pharm. 2015, 83(3), 519-533; doi:10.3797/scipharm.1409-08

The Role of Polydimethylsiloxane in the Molecular Structure of Silica Xerogels Intended for Drug Carriers

Department of Physical Chemistry, Medical University of Gdańsk, al. gen. J. Hallera 107, 80-416 Gdańsk, Poland
Received: 10 September 2014 / Accepted: 1 July 2015 / Published: 1 July 2015
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Abstract

The aim of this study was to prepare and examine polymer/oxide xerogels with metronidazole (MT) as delivery systems for the local application of a drug to a bone. The nanoporous SiO2-CaO and PDMS-modified SiO2-CaO xerogel materials with different amounts of the polymer, polydimethylsiloxane (PDMS), were prepared by the sol-gel method. Characterization assays comprised the analysis of the composite materials by using Fourier transform infrared spectroscopy (FTIR), determining the specific surface area of solids (BET), using X-ray powder diffraction (XRD) and scanning electron microscope (SEM) techniques, and further monitoring in the ultraviolet and visible light regions (UV-Vis) of the in vitro release of the drug (metronidazole) over time. According to these results, the bioactive character and chemical stability of PDMS-modified silica xerogels have been proven. The release of MT from xerogels was strongly correlated with the composition of the matrix. In comparison with the pure oxide matrix, PDMS-modified matrices accelerated the release of the drug through its bigger pores, and additionally, on account of weaker interactions with the drug. The obtained results for the xerogel composites suggest that the metronidazole-loaded xerogels could be promising candidates for formulations in local delivery systems particularly to bone.
Keywords: Sol-gel method; Ormosils; Drug delivery systems Sol-gel method; Ormosils; Drug delivery systems
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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CZARNOBAJ, K. The Role of Polydimethylsiloxane in the Molecular Structure of Silica Xerogels Intended for Drug Carriers. Sci. Pharm. 2015, 83, 519-533.

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