Synthesis and Characterization of Impurities in the Production Process of Lopinavir
by
Ambati V. RAGHAVA REDDY
1,2,
Srinivas GARAGA
1,3,*, 
Chandiran TAKSHINAMOORTHY
1 and
Andra NAIDU
2 1
Chemical Research and Development Department, Aurobindo Pharma Ltd, Survey No: 71&72, Indrakaran Village, Sangareddy Mandal, Medak district, Hyderabad-502329, Telangana State, India
2
Department of Chemistry, Jawaharlal Nehru Technological University Hyderabad, Kukatpally, Hyderabad, Telangana State, India
3
Department of Engineering Chemistry, A. U. College of Engineering (A), Andhra University, Visakhapatnam-530 003, Andhra Pradesh, India
*
Author to whom correspondence should be addressed.
Sci. Pharm. 2015, 83(1), 49-63; https://doi.org/10.3797/scipharm.1407-14
Submission received: 22 July 2014
/
Accepted: 22 September 2014
/
Published: 22 September 2014
Abstract
Lopinavir is an antiretroviral drug used for the inhibition of HIV protease. Four related substances of lopinavir were observed during the manufacturing process of lopinavir in the laboratory and they were identified. The present work describes the origin, synthesis, characterization, and control of these related substances.
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MDPI and ACS Style
RAGHAVA REDDY, A.V.; GARAGA, S.; TAKSHINAMOORTHY, C.; NAIDU, A. Synthesis and Characterization of Impurities in the Production Process of Lopinavir. Sci. Pharm. 2015, 83, 49-63. https://doi.org/10.3797/scipharm.1407-14
AMA Style
RAGHAVA REDDY AV, GARAGA S, TAKSHINAMOORTHY C, NAIDU A. Synthesis and Characterization of Impurities in the Production Process of Lopinavir. Scientia Pharmaceutica. 2015; 83(1):49-63. https://doi.org/10.3797/scipharm.1407-14
Chicago/Turabian StyleRAGHAVA REDDY, Ambati V., Srinivas GARAGA, Chandiran TAKSHINAMOORTHY, and Andra NAIDU. 2015. "Synthesis and Characterization of Impurities in the Production Process of Lopinavir" Scientia Pharmaceutica 83, no. 1: 49-63. https://doi.org/10.3797/scipharm.1407-14
