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Sci. Pharm. 2015, 83(1), 49-63; doi:10.3797/scipharm.1407-14

Synthesis and Characterization of Impurities in the Production Process of Lopinavir

1
Chemical Research and Development Department, Aurobindo Pharma Ltd, Survey No: 71&72, Indrakaran Village, Sangareddy Mandal, Medak district, Hyderabad-502329, Telangana State, India
2
Department of Chemistry, Jawaharlal Nehru Technological University Hyderabad, Kukatpally, Hyderabad, Telangana State, India
3
Department of Engineering Chemistry, A. U. College of Engineering (A), Andhra University, Visakhapatnam-530 003, Andhra Pradesh, India
*
Author to whom correspondence should be addressed.
Received: 22 July 2014 / Accepted: 22 September 2014 / Published: 22 September 2014
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Abstract

Lopinavir is an antiretroviral drug used for the inhibition of HIV protease. Four related substances of lopinavir were observed during the manufacturing process of lopinavir in the laboratory and they were identified. The present work describes the origin, synthesis, characterization, and control of these related substances.
Keywords: Lopinavir; Related substances; Synthesis and Characterization of impurities Lopinavir; Related substances; Synthesis and Characterization of impurities
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

RAGHAVA REDDY, A.V.; GARAGA, S.; TAKSHINAMOORTHY, C.; NAIDU, A. Synthesis and Characterization of Impurities in the Production Process of Lopinavir. Sci. Pharm. 2015, 83, 49-63.

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