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Sci. Pharm. 2015, 83(1), 41-48; doi:10.3797/scipharm.1406-09

Synthesis and Antioxidant Activity of 7-Thio Derivatives of 6,7-Dihydro-1H-cyclopenta[d]pyrimidine-2,4(3H,5H)-dione

1
A. N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, Vavilova str. 28, 119991, Moscow, Russian Federation
2
Institute of Pharmacology and Toxicology, National Academy of Medical Science of Ukraine, Ezhena Pot’je str. 14, 03680, Kyiv, Ukraine
3
T. G. Shevchenko Chernihiv National Pedagogical University, Het’mana Polubotka str. 53, 14013, Chernihiv, Ukraine
*
Author to whom correspondence should be addressed.
Received: 20 June 2014 / Accepted: 29 October 2014 / Published: 29 October 2014
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Abstract

New 7-thio derivatives of 6,7-dihydro-1H-cyclopenta[d]pyrimidine-2,4(3H,5H)-dione have been synthesized by the reaction of 3-cyclohexyl-7-thio-6,7-dihydro-1H-cyclopenta[d]pyrimidine-2,4(3H,5H)-dione with alkylhalogenides. The synthesized compounds were tested for antioxidant activity on the model of Fe2+-dependent oxidation of adrenaline in vitro. It was found that the antiradical activity of 7-thio derivatives of 6,7-dihydro-1H-cyclopenta[d]pyrimidine-2,4(3H,5H)-dione significantly depends on the structure of the substituent which is part of the thioether fragment of the base molecule.
Keywords: 6,7-Dihydro-1H-cyclopenta[d]pyrimidine-2,4(3H,5H)-dione; Alkylation; Antioxidant activity; Fe2+-dependent oxidation of adrenaline 6,7-Dihydro-1H-cyclopenta[d]pyrimidine-2,4(3H,5H)-dione; Alkylation; Antioxidant activity; Fe2+-dependent oxidation of adrenaline
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

KONONEVICH, Y.M.; BOBKOVA, L.S.; SMOLSKI, A.S.; DEMCHENKO, A.M. Synthesis and Antioxidant Activity of 7-Thio Derivatives of 6,7-Dihydro-1H-cyclopenta[d]pyrimidine-2,4(3H,5H)-dione. Sci. Pharm. 2015, 83, 41-48.

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