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Sci. Pharm. 2014, 82(3), 683-696; doi:10.3797/scipharm.1310-19

Release Kinetics of Papaverine Hydrochloride from Tablets with Different Excipients

Department of Applied Pharmacy, Faculty of Pharmacy, Medical University of Lublin, 1 Chodzki Str. 20-093, Lublin, Poland
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Received: 21 October 2013 / Accepted: 16 May 2014 / Published: 16 May 2014
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Abstract

The influence of excipients on the disintegration times of tablets and the release of papaverine hydrochloride (PAP) from tablets were studied. Ten different formulations of tablets with PAP were prepared by direct powder compression. Different binders, disintegrants, fillers, and lubricants were used as excipients. The release of PAP was carried out in the paddle apparatus using 0.1 N HCl as a dissolution medium. The results of the disintegration times of tablets showed that six formulations can be classified as fast dissolving tablets (FDT). FDT formulations contained Avicel PH 101, Avicel PH 102, mannitol, β-lactose, PVP K 10, gelatinized starch (CPharmGel), Prosolv Easy Tab, Prosolv SMCC 90, magnesium stearate, and the addition of disintegrants such as AcDiSol and Kollidon CL. Drug release kinetics were estimated by the zero- and first-order, Higuchi release rate, and Korsmeyer-Peppas models. Two formulations of the tablets containing PVP (K10) (10%), CPharmGel (10% and 25%), and Prosolv Easy Tab (44% and 60%) without the addition of a disintegrant were well-fitted to the kinetics models such as the Higuchi and zero-order, which are suitable for controlled- or sustained-release.
Keywords: Excipients; Kinetic model; Papaverine; Release study; Tablets Excipients; Kinetic model; Papaverine; Release study; Tablets
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

KASPEREK, R.; POLSKI, A.; ZIMMER, Ł.; POLESZAK, E. Release Kinetics of Papaverine Hydrochloride from Tablets with Different Excipients. Sci. Pharm. 2014, 82, 683-696.

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