Selective Phosphodiesterase 4B Inhibitors: A Review
AbstractPhosphodiesterase 4B (PDE4B) is a member of the phosphodiesterase family of proteins that plays a critical role in regulating intracellular levels of cyclic adenosine monophosphate (cAMP) by controlling its rate of degradation. It has been demonstrated that this isoform is involved in the orchestra of events which includes inflammation, schizophrenia, cancers, chronic obstructive pulmonary disease, contractility of the myocardium, and psoriatic arthritis. Phospho-diesterase 4B has constituted an interesting target for drug development. In recent years, a number of PDE4B inhibitors have been developed for their use as therapeutic agents. In this review, an up-to-date status of the inhibitors investigated for the inhibition of PDE4B has been given so that this rich source of structural information of presently known PDE4B inhibitors could be helpful in generating a selective and potent inhibitor of PDE4B.
Scifeed alert for new publicationsNever miss any articles matching your research from any publisher
- Get alerts for new papers matching your research
- Find out the new papers from selected authors
- Updated daily for 49'000+ journals and 6000+ publishers
- Define your Scifeed now
AZAM, M.A.; TRIPURANENI, N.S. Selective Phosphodiesterase 4B Inhibitors: A Review. Sci. Pharm. 2014, 82, 453-482.
AZAM MA, TRIPURANENI NS. Selective Phosphodiesterase 4B Inhibitors: A Review. Scientia Pharmaceutica. 2014; 82(3):453-482.Chicago/Turabian Style
AZAM, Mohammed A.; TRIPURANENI, Naga S. 2014. "Selective Phosphodiesterase 4B Inhibitors: A Review." Sci. Pharm. 82, no. 3: 453-482.