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Sci. Pharm. 2014, 82(3), 453-482; doi:10.3797/scipharm.1404-08

Selective Phosphodiesterase 4B Inhibitors: A Review

Department of Pharmaceutical Chemistry, J. S. S. College of Pharmacy, Ootacamund-643001, Tamil Nadu, India
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Received: 19 April 2014 / Accepted: 10 June 2014 / Published: 10 June 2014
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Abstract

Phosphodiesterase 4B (PDE4B) is a member of the phosphodiesterase family of proteins that plays a critical role in regulating intracellular levels of cyclic adenosine monophosphate (cAMP) by controlling its rate of degradation. It has been demonstrated that this isoform is involved in the orchestra of events which includes inflammation, schizophrenia, cancers, chronic obstructive pulmonary disease, contractility of the myocardium, and psoriatic arthritis. Phospho-diesterase 4B has constituted an interesting target for drug development. In recent years, a number of PDE4B inhibitors have been developed for their use as therapeutic agents. In this review, an up-to-date status of the inhibitors investigated for the inhibition of PDE4B has been given so that this rich source of structural information of presently known PDE4B inhibitors could be helpful in generating a selective and potent inhibitor of PDE4B.
Keywords: Phosphodiesterases (PDE) enzymes; Cyclic adenosine monophosphate; Selective PDE inhibitors; Chronic obstructive pulmonary disease; Antiproliferative activity; PDE4B Phosphodiesterases (PDE) enzymes; Cyclic adenosine monophosphate; Selective PDE inhibitors; Chronic obstructive pulmonary disease; Antiproliferative activity; PDE4B
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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AZAM, M.A.; TRIPURANENI, N.S. Selective Phosphodiesterase 4B Inhibitors: A Review. Sci. Pharm. 2014, 82, 453-482.

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