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Sci. Pharm. 2013, 81(2), 607-624; doi:10.3797/scipharm.1302-02

A Biological Approach to the Synthesis of Silver Nanoparticles with Streptomyces sp JAR1 and its Antimicrobial Activity

School of Biosciences and Technology, VIT University, Vellore, Tamil Nadu, India
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Received: 5 February 2013 / Accepted: 28 March 2013 / Published: 28 March 2013
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Abstract

The biological approach to synthesize metal nanoparticles is an important aspect of current nanotechnology research. Silver nanoparticles have been well-known for their inhibitory and antimicrobial effects. The ever-increasing antibiotic resistance in pathogenic and opportunistic microorganisms is a major threat to the health care industry. In the present investigation, silver nanoparticles have been successfully biosynthesized by Streptomyces sp JAR1. Biosynthesized silver nanoparticles were characterized by means of several analytical techniques including a UV-Visible spectrophotometer, Fourier transform infrared spectroscopy, X-ray diffraction pattern analysis, and atomic force microscopy. An evaluation of the antimicrobial activity of silver nanoparticles (AgNPs) was carried out against clinically important pathogenic microorganisms. The metal nanoparticles were also evaluated for their combined effects with antibiotics against the clinical pathogens. The anti-bacterial activities of the antibiotics increased in the presence of the biologically synthesized AgNPs against the clinically important pathogens. The highest enhancing effect was observed for erythromycin against the test pathogens.
Keywords: Streptomyces sp JAR1; Metal nanoparticles; Synergistic effect; Antibiotics; XRD pattern Streptomyces sp JAR1; Metal nanoparticles; Synergistic effect; Antibiotics; XRD pattern
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

CHAUHAN, R.; KUMAR, A.; ABRAHAM, J. A Biological Approach to the Synthesis of Silver Nanoparticles with Streptomyces sp JAR1 and its Antimicrobial Activity. Sci. Pharm. 2013, 81, 607-624.

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