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Sci. Pharm. 2013, 81(2), 309-328; doi:10.3797/scipharm.1302-08

An Update on the Status of Potent Inhibitors of Metallo-β-Lactamases

1
Chemistry Department, Islamia College University, Peshawar-25120, Pakistan
2
Institute of Chemical Sciences, University of Peshawar, Peshawar-25120, Pakistan
*
Author to whom correspondence should be addressed.
Received: 18 February 2013 / Accepted: 28 March 2013 / Published: 28 March 2013
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Abstract

The production of metallo-β-lactamases is the most important strategy by which pathogenic bacteria become resistant to currently known β-lactam antibiotics. The emergence of these enzymes is particularly concerning for the future treatment of bacterial infections. There are no clinically available drugs capable of inhibiting any of the metallo-β-lactamases, so there is an urgent need to find such inhibitors. In this review, an up-to-date status of the inhibitors investigated for the inhibition of metallo-β-lactamases has been given so that this rich source of structural information of presently known metallo-β-lactamases could be helpful in generating a broad-spectrum potent inhibitor of metallo-β-lactamases.
Keywords: Metallo-beta-lactamases; Inhibition; Thiol; β-Lactam analogues; Peptides; Biphenyl tetrazoles; Triazoles Metallo-beta-lactamases; Inhibition; Thiol; β-Lactam analogues; Peptides; Biphenyl tetrazoles; Triazoles
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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FARIDOON; ISLAM, N.U. An Update on the Status of Potent Inhibitors of Metallo-β-Lactamases. Sci. Pharm. 2013, 81, 309-328.

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