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Sci. Pharm. 2012, 80(4), 867-878; https://doi.org/10.3797/scipharm.1209-03 (registering DOI)
Cytotoxic and Antifungal Activities of Diverse α-Naphthylamine Derivatives
Laboratorio de Química Orgánica y Biomolecular, Escuela de Química, Universidad Industrial de Santander, A. A. 678, Bucaramanga, Colombia
Farmacognosia, Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario, Suipacha 531, (2000) Rosario, Argentina
Grupo de Investigaciones Ambientales, Facultad de Química Ambiental, Universidad Santo Tomás, A. A. 1076, Bucaramanga, Colombia
Centro de Investigaciones Farmacognósticas de la Flora Panameña (CIFLORPAN), Facultad de Farmacia, Universidad de Panamá, Panamá, Republic of Panama
Author to whom correspondence should be addressed.
Received: 10 September 2012 / Accepted: 23 October 2012 / Published: 23 October 2012
Abstract Diverse α-naphthylamine derivatives were easily prepared from corresponding aldimines derived from commercially available α-naphthaldehyde and anilines or isomeric pyridinecarboxyaldehydes and α-naphthylamine. The secondary amines obtained were tested as possible antifungal and cytotoxic agents. The diverse N-aryl-N-[1-(1-naphthyl)but-3-enyl]amines obtained were active (IC50 < 10 μg/mL) against breast (MCF-7), non-small cell lung (H-460), and central nervous system (SF-268) human cancer cell lines, while N-(pyridinylmethyl)-naphthalen-1-amines resulted in activity against (MIC 25–32 μg/mL) some human opportunistic pathogenic fungi including yeasts, hialohyphomycetes, and dermatophytes.
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KOUZNETSOV, V.V.; ZACCHINO, S.A.; SORTINO, M.; VARGAS MÉNDEZ, L.Y.; GUPTA, M.P. Cytotoxic and Antifungal Activities of Diverse α-Naphthylamine Derivatives. Sci. Pharm. 2012, 80, 867-878.
KOUZNETSOV VV, ZACCHINO SA, SORTINO M, VARGAS MÉNDEZ LY, GUPTA MP. Cytotoxic and Antifungal Activities of Diverse α-Naphthylamine Derivatives. Scientia Pharmaceutica. 2012; 80(4):867-878.
KOUZNETSOV, Vladímir V.; ZACCHINO, Susana A.; SORTINO, Maximiliano; VARGAS MÉNDEZ, Leonor Y.; GUPTA, Mahabir P. 2012. "Cytotoxic and Antifungal Activities of Diverse α-Naphthylamine Derivatives." Sci. Pharm. 80, no. 4: 867-878.
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