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Sci. Pharm. 2012, 80(4), 867-878; doi:10.3797/scipharm.1209-03

Cytotoxic and Antifungal Activities of Diverse α-Naphthylamine Derivatives

1
Laboratorio de Química Orgánica y Biomolecular, Escuela de Química, Universidad Industrial de Santander, A. A. 678, Bucaramanga, Colombia
2
Farmacognosia, Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario, Suipacha 531, (2000) Rosario, Argentina
3
Grupo de Investigaciones Ambientales, Facultad de Química Ambiental, Universidad Santo Tomás, A. A. 1076, Bucaramanga, Colombia
4
Centro de Investigaciones Farmacognósticas de la Flora Panameña (CIFLORPAN), Facultad de Farmacia, Universidad de Panamá, Panamá, Republic of Panama
*
Author to whom correspondence should be addressed.
Received: 10 September 2012 / Accepted: 23 October 2012 / Published: 23 October 2012
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Abstract

Diverse α-naphthylamine derivatives were easily prepared from corresponding aldimines derived from commercially available α-naphthaldehyde and anilines or isomeric pyridinecarboxyaldehydes and α-naphthylamine. The secondary amines obtained were tested as possible antifungal and cytotoxic agents. The diverse N-aryl-N-[1-(1-naphthyl)but-3-enyl]amines obtained were active (IC50 < 10 μg/mL) against breast (MCF-7), non-small cell lung (H-460), and central nervous system (SF-268) human cancer cell lines, while N-(pyridinylmethyl)-naphthalen-1-amines resulted in activity against (MIC 25–32 μg/mL) some human opportunistic pathogenic fungi including yeasts, hialohyphomycetes, and dermatophytes.
Keywords: α-Naphthylamines; Antifungal properties; Cytotoxic agents α-Naphthylamines; Antifungal properties; Cytotoxic agents
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

KOUZNETSOV, V.V.; ZACCHINO, S.A.; SORTINO, M.; VARGAS MÉNDEZ, L.Y.; GUPTA, M.P. Cytotoxic and Antifungal Activities of Diverse α-Naphthylamine Derivatives. Sci. Pharm. 2012, 80, 867-878.

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