Cytotoxic and Antifungal Activities of Diverse α-Naphthylamine Derivatives
AbstractDiverse α-naphthylamine derivatives were easily prepared from corresponding aldimines derived from commercially available α-naphthaldehyde and anilines or isomeric pyridinecarboxyaldehydes and α-naphthylamine. The secondary amines obtained were tested as possible antifungal and cytotoxic agents. The diverse N-aryl-N-[1-(1-naphthyl)but-3-enyl]amines obtained were active (IC50 < 10 μg/mL) against breast (MCF-7), non-small cell lung (H-460), and central nervous system (SF-268) human cancer cell lines, while N-(pyridinylmethyl)-naphthalen-1-amines resulted in activity against (MIC 25–32 μg/mL) some human opportunistic pathogenic fungi including yeasts, hialohyphomycetes, and dermatophytes.
Scifeed alert for new publicationsNever miss any articles matching your research from any publisher
- Get alerts for new papers matching your research
- Find out the new papers from selected authors
- Updated daily for 49'000+ journals and 6000+ publishers
- Define your Scifeed now
KOUZNETSOV, V.V.; ZACCHINO, S.A.; SORTINO, M.; VARGAS MÉNDEZ, L.Y.; GUPTA, M.P. Cytotoxic and Antifungal Activities of Diverse α-Naphthylamine Derivatives. Sci. Pharm. 2012, 80, 867-878.
KOUZNETSOV VV, ZACCHINO SA, SORTINO M, VARGAS MÉNDEZ LY, GUPTA MP. Cytotoxic and Antifungal Activities of Diverse α-Naphthylamine Derivatives. Scientia Pharmaceutica. 2012; 80(4):867-878.Chicago/Turabian Style
KOUZNETSOV, Vladímir V.; ZACCHINO, Susana A.; SORTINO, Maximiliano; VARGAS MÉNDEZ, Leonor Y.; GUPTA, Mahabir P. 2012. "Cytotoxic and Antifungal Activities of Diverse α-Naphthylamine Derivatives." Sci. Pharm. 80, no. 4: 867-878.