Cytotoxic and Antifungal Activities of Diverse α-Naphthylamine Derivatives
by
Vladímir V. KOUZNETSOV
1,*, 
Susana A. ZACCHINO
2,
Maximiliano SORTINO
2,
Leonor Y. VARGAS MÉNDEZ
3 and
Mahabir P. GUPTA
4 1
Laboratorio de Química Orgánica y Biomolecular, Escuela de Química, Universidad Industrial de Santander, A. A. 678, Bucaramanga, Colombia
2
Farmacognosia, Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario, Suipacha 531, (2000) Rosario, Argentina
3
Grupo de Investigaciones Ambientales, Facultad de Química Ambiental, Universidad Santo Tomás, A. A. 1076, Bucaramanga, Colombia
4
Centro de Investigaciones Farmacognósticas de la Flora Panameña (CIFLORPAN), Facultad de Farmacia, Universidad de Panamá, Panamá, Republic of Panama
*
Author to whom correspondence should be addressed.
Sci. Pharm. 2012, 80(4), 867-878; https://doi.org/10.3797/scipharm.1209-03
Submission received: 10 September 2012
/
Accepted: 23 October 2012
/
Published: 23 October 2012
Abstract
Diverse α-naphthylamine derivatives were easily prepared from corresponding aldimines derived from commercially available α-naphthaldehyde and anilines or isomeric pyridinecarboxyaldehydes and α-naphthylamine. The secondary amines obtained were tested as possible antifungal and cytotoxic agents. The diverse N-aryl-N-[1-(1-naphthyl)but-3-enyl]amines obtained were active (IC50 < 10 μg/mL) against breast (MCF-7), non-small cell lung (H-460), and central nervous system (SF-268) human cancer cell lines, while N-(pyridinylmethyl)-naphthalen-1-amines resulted in activity against (MIC 25–32 μg/mL) some human opportunistic pathogenic fungi including yeasts, hialohyphomycetes, and dermatophytes.
Keywords:
α-Naphthylamines; Antifungal properties; Cytotoxic agents
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MDPI and ACS Style
KOUZNETSOV, V.V.; ZACCHINO, S.A.; SORTINO, M.; VARGAS MÉNDEZ, L.Y.; GUPTA, M.P. Cytotoxic and Antifungal Activities of Diverse α-Naphthylamine Derivatives. Sci. Pharm. 2012, 80, 867-878. https://doi.org/10.3797/scipharm.1209-03
AMA Style
KOUZNETSOV VV, ZACCHINO SA, SORTINO M, VARGAS MÉNDEZ LY, GUPTA MP. Cytotoxic and Antifungal Activities of Diverse α-Naphthylamine Derivatives. Scientia Pharmaceutica. 2012; 80(4):867-878. https://doi.org/10.3797/scipharm.1209-03
Chicago/Turabian StyleKOUZNETSOV, Vladímir V., Susana A. ZACCHINO, Maximiliano SORTINO, Leonor Y. VARGAS MÉNDEZ, and Mahabir P. GUPTA. 2012. "Cytotoxic and Antifungal Activities of Diverse α-Naphthylamine Derivatives" Scientia Pharmaceutica 80, no. 4: 867-878. https://doi.org/10.3797/scipharm.1209-03
