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Sci. Pharm. 2012, 80(3), 531-546; doi:10.3797/scipharm.1204-23

Design, Synthesis, and Antitumor Evaluation of Novel Pyrazolo[3,4-d]pyrimidine Derivatives

Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Cairo University, Cairo, Egypt
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Received: 23 April 2012 / Accepted: 25 June 2012 / Published: 25 June 2012
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Abstract

A new series of pyrazolo[3,4-d]pyrimidines has been synthesized. The new compounds were tested for their antitumor activity on 60 different cell lines, and some of the compounds were found to have potent antitumor activity. In particular, 2-hydroxybenzaldehyde [1-(4-chlorophenyl)-3-methyl-1H-pyrazolo-[3,4-d]pyrimidin-4-yl]hydrazone (VIIa) was found to be the most effective among the other derivatives, showing IC50 values of 0.326 to 4.31 μM on 57 different cell lines.
Keywords: Pyrazolopyrimidines; Antitumor Activity; Cytotoxic Activity; Synthesis Pyrazolopyrimidines; Antitumor Activity; Cytotoxic Activity; Synthesis
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

KANDEEL, M.M.; MOHAMED, L.W.; ABD EL HAMID, M.K.; NEGMELDIN, A.T. Design, Synthesis, and Antitumor Evaluation of Novel Pyrazolo[3,4-d]pyrimidine Derivatives. Sci. Pharm. 2012, 80, 531-546.

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